Andrew L Larson

US Patent:

8103076, Jan 24, 2012

Filed:

Oct 31, 2008

Appl. No.:

12/262651

Inventors:

Andrew Christian Larson - Kildeer IL, US
Reed Ali Omary - Chicago IL, US
Dingxin Wang - Evanston IL, US

Assignee:

Northwestern University - Evanston IL

International Classification:

G06K 9/20

US Classification:

382130, 382132, 128922, 250302, 600363

Abstract:

A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors. The perfusion imaging method can be acquired using magnetic resonance, x-ray computed tomography, or radionuclide imaging.

US Patent:

D692447, Oct 29, 2013

Filed:

Nov 4, 2011

Appl. No.:

29/405735

Inventors:

Pamela M. Marshall - Lake Zurich IL, US
Andrew Larson - Chicago IL, US
Michael Pavlik - Buffalo Grove IL, US

Assignee:

Allstate Insurance Company - Northbrook IL

International Classification:

1404

US Classification:

D14486

US Patent:

D692905, Nov 5, 2013

Filed:

Nov 4, 2011

Appl. No.:

29/405731

Inventors:

Pamela M. Marshall - Lake Zurich IL, US
Andrew Larson - Chicago IL, US
Michael Pavlik - Buffalo Grove IL, US

Assignee:

Allstate Insurance Company - Northbrook IL

International Classification:

1404

US Classification:

D14486

US Patent:

20080144900, Jun 19, 2008

Filed:

Oct 23, 2006

Appl. No.:

11/585424

Inventors:

Debiao Li - Naperville IL, US
Jaeseok Park - Baiersdorf, GE
Andrew C. Larson - Kildeer IL, US

International Classification:

G06K 9/00

US Classification:

382130

Abstract:

In a magnetic resonance imaging method and apparatus, sensitivity encoding (SENSE) with radial sampling trajectories combines the gridding principle with conjugate-gradient least-squares (CGLS) iterative reconstruction. Radial k-space is mapped to a larger matrix by a resealing factor to eliminate the computational complexity of conventional gridding and density compensation. To improve convergence rate of high spatial frequency signals in CGLS iteration, a spatially invariant de-blurring k-space filter uses the impulse response of the system. This filter is incorporated into the SENSE reconstruction as preconditioning. The optimal number of iterations represents a tradeoff between image accuracy and noise over several reduction factors.

US Patent:

20110301401, Dec 8, 2011

Filed:

Jun 8, 2011

Appl. No.:

13/155925

Inventors:

Andrew C. Larson - Kildeer IL, US
Andrew C. Gordon - Chicago IL, US
Reed A. Omary - Wilmette IL, US

International Classification:

A61N 5/02
A61P 35/00
A61K 51/02

US Classification:

600 2, 424 161

Abstract:

The present invention relates to compositions and methods for increasing tissue-radiosensitivity through induction of local hyperthermia. In particular, the present invention provides superparamagnetic, paramagnetic, or ferromagnetic radioactive particles that heat surrounding tissue upon magnetic induction, and methods of use thereof. In some embodiments, the present invention provides compositions and methods for thermoradiotherapy (e.g. anti-tumor therapy).

US Patent:

20120089009, Apr 12, 2012

Filed:

Oct 11, 2011

Appl. No.:

13/270977

Inventors:

Reed A. Omary - Wilmette IL, US
Andrew C. Larson - Kildeer IL, US
Samdeep K. Mouli - Chicago IL, US
Aaron C. Eifler - Chicago IL, US
Yang Guo - Chicago IL, US

International Classification:

A61B 5/055
B32B 5/16
C07H 15/24
A61N 1/30
B82Y 5/00

US Classification:

600411, 536 64, 604 20, 428402, 977773

Abstract:

Methods, systems, and apparatus are disclosed to provide delivery of nanoparticles to tissue using electro-nanotherapy or nanoablation.

US Patent:

20120101363, Apr 26, 2012

Filed:

Oct 13, 2011

Appl. No.:

13/272857

Inventors:

Andrew C. Gordon - Chicago IL, US
Andrew C. Larson - Kildeer IL, US
Reed A. Omary - Wilmette IL, US

International Classification:

A61N 2/00
A61B 5/055
A61B 17/03

US Classification:

600411, 600 9

Abstract:

Methods, systems, and apparatus are disclosed to provide treatment to patient tissue using medical hardware incorporating magnetic material. Methods, systems, and apparatus are disclosed to provide magnetic induction heating of cells at a tissue site in a patient.

US Patent:

20120277283, Nov 1, 2012

Filed:

Aug 4, 2010

Appl. No.:

13/388630

Inventors:

Chad A. Mirkin - Wilmette IL, US
Reed A. Omary - Wilmette IL, US
Aaron Eifler - Chicago IL, US
Samdeep K. Mouli - Chicago IL, US
Kaylin McMahon - Chicago IL, US
Andrew Larson - Kildeer IL, US

International Classification:

A61K 31/7088
A61P 35/00

US Classification:

514 44 A, 514 44 R

Abstract:

The present invention is directed to compositions and methods of localized delivery of a functionalized nanoparticle.