Andrew Luk

US Patent:

20090074831, Mar 19, 2009

Filed:

Sep 18, 2007

Appl. No.:

11/857285

Inventors:

Robert Falotico - Belle Mead NJ, US
Andrew Sheung-King Luk - Castro Valley CA, US
Theodore L. Parker - Danville CA, US
Jonathon Z. Zhao - Belle Mead NJ, US
Lei Zhao - Chester Springs PA, US

International Classification:

A61K 9/00
A61K 31/427
A61K 31/4439

US Classification:

424423, 514369, 514342

Abstract:

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and atherosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

US Patent:

20120130481, May 24, 2012

Filed:

Dec 17, 2010

Appl. No.:

12/971083

Inventors:

Robert Falotico - Belle Mead NJ, US
Andrew Luk - Pleasanton CA, US
Theodore L. Parker - Danville CA, US
Jonathon Z. Zhao - Belle Mead NJ, US

International Classification:

A61F 2/82

US Classification:

623 142

Abstract:

A stent or other implantable medical device for the local delivery of a selective adenosine receptor agonist may be utilized in combination with other therapeutic agents to reduce myocardial injury following an acute myocardial infarction. As soon as possible following an acute myocardial infarction a stent or other suitable device comprising and capable of delivering a selective adenosine receptor agonist is positioned in the blood vessel with the occlusion responsible for causing the infarct. Once in position , the stent or other intraluminal device is deployed to remove the occlusion and reestablish blood flow to the specific area, region or tissue volume of the heart. Over a given period of time the selective adenosine receptor agonist alone or in combination with other therapeutic agents elute from the stent or other device into the downstream coronary blood flow into the hypoxic cardiac tissue for a time sufficient to reduce the level of myocardial injury.