Andrew T Maynard

US Patent:

6706729, Mar 16, 2004

Filed:

May 16, 2001

Appl. No.:

09/701451

Inventors:

James A. Turpin - Frederick MD
Yongsheng Song - East Haven CT
Ettore Appella - Chevy Chase MD
John K. Inman - Bethesda MD
David G. Covell - Chevy Chase MD
William G. Rice - Madison CT
Anders Wallqvist - Frederick MD
Andrew Maynard - Wilmington DE
Mingjun Huang - Rockville MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 3144

US Classification:

514298, 514354, 514355, 546298

Abstract:

This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.

US Patent:

7625917, Dec 1, 2009

Filed:

Dec 16, 2003

Appl. No.:

10/738062

Inventors:

James A. Turpin - Frederick MD, US
Yongsheng Song - East Haven CT, US
Ettore Appella - Chevy Chase MD, US
John K. Inman - Bethesda MD, US
David G. Covell - Chevy Chase MD, US
William G. Rice - Madison CT, US
Anders Wallqvist - Frederick MD, US
Andrew Maynard - Wilmington DE, US
Mingjun Huang - Rockville MD, US

International Classification:

A61K 31/435
A61K 39/12

US Classification:

514277, 546 1, 546298, 435 5, 4242041, 514706

Abstract:

This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.

US Patent:

8357711, Jan 22, 2013

Filed:

Mar 20, 2008

Appl. No.:

12/052593

Inventors:

Brian Edward Marron - Durham NC, US
Paul Christopher Fritch - Cary NC, US
Christopher John Markworth - Durham NC, US
Andrew Thomas Maynard - Durham NC, US
Nigel Alan Swain - Sandwich, GB

Assignee:

Pfizer Limited - Sandwich
Icagen, Inc. - Durham NC

International Classification:

A61K 31/427

US Classification:

514370, 548190

Abstract:

The invention is directed to compounds of the formula.

US Patent:

20130072471, Mar 21, 2013

Filed:

Nov 15, 2012

Appl. No.:

13/677849

Inventors:

Brian Edward Marron - Durham NC, US
Paul Christopher Fritch - Cary NC, US
Christopher John Markworth - Durham NC, US
Andrew Thomas Maynard - Durham NC, US
Nigel Alan Swain - Sandwich, GB

International Classification:

C07D 471/04
C07D 285/135
C07D 417/12
C07D 277/52
C07D 285/08

US Classification:

51421115, 548194, 514370, 548128, 514361, 544 60, 5142278, 540544, 514363

Abstract:

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

US Patent:

20230104936, Apr 6, 2023

Filed:

Dec 18, 2020

Appl. No.:

17/786607

Inventors:

- Cambridge MA, US
Jeffrey Owen Saunders - Lincoln MA, US
Harit Umesh Vora - North Andover MA, US
Jian Lin - Acton MA, US
Andrew Thomas Maynard - Winchester MA, US
Erik Lee Meredith - Hudson MA, US

International Classification:

C07D 401/04
C07D 211/14
C07D 213/83

Abstract:

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.