Andrew Donald Nelson

US Patent:

6605272, Aug 12, 2003

Filed:

Aug 3, 2001

Appl. No.:

09/923246

Inventors:

Julia E. Novak - Bainbridge Island WA
Scott R. Presnell - Tacoma WA
Cindy A. Sprecher - Seattle WA
Donald C. Foster - Lake Forest Park WA
Richard D. Holly - Seattle WA
Jane A. Gross - Seattle WA
Janet V. Johnston - Seattle WA
Andrew J. Nelson - Shoreline WA
Stacey R. Dillon - Seattle WA
Angela K. Hammond - Maple Valley WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 4500

US Classification:

424 852, 424 851, 4241691, 4241731, 4241741, 514 2, 514 12

Abstract:

The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

US Patent:

6686178, Feb 3, 2004

Filed:

Nov 15, 2002

Appl. No.:

10/295723

Inventors:

Julia E. Novak - Bainbridge Island WA
Scott R. Presnell - Tacoma WA
Cindy A. Sprecher - Seattle WA
Donald C. Foster - Lake Forest Park WA
Richard D. Holly - Seattle WA
Jane A. Gross - Seattle WA
Janet V. Johnston - Seattle WA
Andrew J. Nelson - Shoreline WA
Stacey R. Dillon - Seattle WA
Angela K. Hammond - Maple Valley WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C12N 1524

US Classification:

435 6952, 435 691, 435 701, 4353201, 435325, 4241301, 4241431, 536 231, 536 241

Abstract:

The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

US Patent:

6754314, Jun 22, 2004

Filed:

Oct 2, 2002

Appl. No.:

10/264061

Inventors:

Michael Wengrovitz - Concord MA
Andrew Nelson - Lynnfield MA

Assignee:

Alcatel - Paris

International Classification:

H04M 1100

US Classification:

379 9301, 340 729, 340 731

Abstract:

A communication system is disclosed including a first digital telephone set, a second digital telephone set, or its processing equivalent, having a private branch exchange (PBX)-paging server interface, and a PBX operative between the first digital telephone set and the second digital telephone set, wherein the second digital telephone set transmits text messages received from the first digital telephone set to a paging server via the PBX-paging server interface and wherein the paging server transmits the text messages to a pager. Also disclosed is a communication method including the steps of keying-in a text message on a first digital telephone set, transmitting the text message, via a private branch exchange (PBX), from the first digital telephone set to a second digital telephone set having a PBX-paging server interface, transmitting the text message, via the PBX-paging server interface, from the second digital telephone set to a paging server, transmitting the text message from the paging server to a pager, and displaying the text message on the pager.

US Patent:

6777539, Aug 17, 2004

Filed:

Apr 3, 2001

Appl. No.:

09/825561

Inventors:

Cindy A. Sprecher - Seattle WA
Julia E. Novak - Bainbridge Island WA
James W. West - Seattle WA
Scott R. Presnell - Tacoma WA
Richard D. Holly - Seattle WA
Andrew J. Nelson - Shoreline WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 14435

US Classification:

530350, 530351

Abstract:

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zlapha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

US Patent:

7189695, Mar 13, 2007

Filed:

Jun 18, 2004

Appl. No.:

10/872087

Inventors:

Cindy A. Sprecher - Seattle WA, US
Julia E. Novak - Bainbridge Island WA, US
James W. West - Seattle WA, US
Richard D. Holly - Seattle WA, US
Andrew J. Nelson - Shoreline WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 38/17
C07K 14/435

US Classification:

514 12, 530350

Abstract:

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zlapha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

US Patent:

7473765, Jan 6, 2009

Filed:

Sep 10, 2003

Appl. No.:

10/659684

Inventors:

Julia E. Novak - Bainbridge Island WA, US
Scott R. Presnell - Tacoma WA, US
Cindy A. Sprecher - Seattle WA, US
Donald C. Foster - Lake Forest Park WA, US
Richard D. Holly - Seattle WA, US
Jane A. Gross - Seattle WA, US
Janet V. Johnston - Seattle WA, US
Andrew J. Nelson - Shoreline WA, US
Stacey R. Dillon - Seattle WA, US
Angela K. Hammond - Maple Valley WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 14/52
C07K 14/00
A61K 38/20
C12N 15/00
C07H 21/04

US Classification:

530351, 530350, 424 852

Abstract:

The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

US Patent:

7491800, Feb 17, 2009

Filed:

Feb 26, 2004

Appl. No.:

10/787442

Inventors:

Julia E. Novak - Bainbridge Island WA, US
Scott R. Presnell - Tacoma WA, US
Cindy A. Sprecher - Seattle WA, US
Donald C. Foster - Lake Forest Park WA, US
Richard D. Holly - Seattle WA, US
Jane A. Gross - Seattle WA, US
Janet V. Johnston - Seattle WA, US
Andrew J. Nelson - Shoreline WA, US
Stacey R. Dillon - Seattle WA, US
Angela K. Hammond - Maple Valley WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 17/00
C07K 14/00
A61K 39/00

US Classification:

530351, 530350, 4241851

Abstract:

The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

US Patent:

7569670, Aug 4, 2009

Filed:

Oct 20, 2006

Appl. No.:

11/551368

Inventors:

Julia E. Novak - Bainbridge Island WA, US
Scott R. Presnell - Tacoma WA, US
Cindy A. Sprecher - Seattle WA, US
Donald C. Foster - Lake Forest Park WA, US
Richard D. Holly - Seattle WA, US
Jane A. Gross - Seattle WA, US
Janet V. Johnston - Seattle WA, US
Andrew J. Nelson - Shoreline WA, US
Stacey R. Dillon - Seattle WA, US
Angela K. Hammond - Maple Valley WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 17/00
C07K 14/00
A61K 39/00

US Classification:

530351, 530350, 4241851

Abstract:

Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.