Andrew M Peters

US Patent:

6573246, Jun 3, 2003

Filed:

Aug 23, 2000

Appl. No.:

09/644470

Inventors:

Robert Bittman - Roslyn Heights NY
Ravi K. Erukulla - Plainsboro NY
Andrew C. Peters - Yardley PA
Eric G. Mayhew - Monmouth Junction NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ
The Research Foundation of the City University of New York - New York NY

International Classification:

A61K 3170

US Classification:

514 25, 514 62, 536 41, 536 552

Abstract:

This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage, 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.

US Patent:

61537365, Nov 28, 2000

Filed:

Sep 26, 1996

Appl. No.:

8/722881

Inventors:

Robert Bittman - Roslyn Heights NY
Ravi K. Erukulla - Plainsboro NJ
Andrew C. Peters - Yardley PA
Eric G. Mayhew - Monmouth Junction NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ

International Classification:

C07H 1506
C07H 506
A61K 3170

US Classification:

536 41

Abstract:

This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage; 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.