Andrew D Peterson

US Patent:

56611382, Aug 26, 1997

Filed:

Oct 3, 1996

Appl. No.:

8/726059

Inventors:

Andrew C. Peterson - Madison WI
Rudolf Franzmair - Linz, AT
Haridasan K. Nair - Madison WI

Assignee:

Clarion Pharmaceutical, Inc. - Madison WI

International Classification:

A61K 31685
C07F 910

US Classification:

514 77

Abstract:

Novel (o-acyl-p-N-acylamino-phenyl)-O-phosphoethanolamines and pharmaceutically acceptable salts thereof having anti-inflammatory activity, and pharmaceutical compositions containing same are disclosed. Certain novel intermediates are also disclosed.

US Patent:

58830847, Mar 16, 1999

Filed:

Jun 8, 1998

Appl. No.:

/093128

Inventors:

Andrew C. Peterson - Madison WI
Thaddeus P. Pruss - Madison WI

Assignee:

Clarion Pharmaceuticals Inc. - Madison WI

International Classification:

A61K 31685
A61K 31355

US Classification:

514 78

Abstract:

Disclosed is a method of treating respiratory diseases comprising treating the lungs with an therapeutically-effective amount of. alpha. -tocopheryl-phosphocholine or a pharmaceutically-acceptable salt thereof, wherein the amount is administered is effective to make breathing easier.

US Patent:

58045694, Sep 8, 1998

Filed:

Mar 14, 1997

Appl. No.:

8/818378

Inventors:

Andrew C. Peterson - Madison WI
Haridasan K. Nair - Madison WI

Assignee:

Clarion Pharmaceuticals Inc. - Madison WI

International Classification:

A61K 31685

US Classification:

514 77

Abstract:

Disclosed are the use of certain cycloalkyl- and aryl-phosphoethanolamines as anti-inflammatory, anti-arrhythmic and local anesthetic agents. These therapeutically active cycloalkyl- and aryl-phosphoethanolamines are of the general Formula I: R--O--PEA I wherein R is an unsubstituted or a substituted C. sub. 5-7 cycloalkyl or an unsubstituted or a substituted phenyl in which each substituent is hydrogen or an unsubstituted or substituted straight or branched C. sub. 1-4 alkyl or C. sub. 2-4 alkenyl, said substitution being one or more of C. sub. 1-4 alkoxy, halo or cyano; and --O--PEA represents a phosphoethanolamine substituent. Also disclosed are intermediates for producing Formula I compounds.

US Patent:

58278362, Oct 27, 1998

Filed:

Nov 15, 1996

Appl. No.:

8/749512

Inventors:

Andrew C. Peterson - Madison WI
Thaddeus P. Pruss - Madison WI
Parvin T. Yazdi - Madison WI

Assignee:

Clarion Pharmaceuticals Inc. - Madison WI

International Classification:

A61K 3166
C07F 910

US Classification:

514 77

Abstract:

Retinoyl substituted glycerophosphoethanolamines are disclosed having the general Formula I: ##STR1## wherein one of A, B or C is a fatty ether substituent, one is a natural or synthetic retinoid ester substituent, and one is a phosphoethanolamine substituent, provided that A, B and C are each a different substituent. The optical and geometric isomers of compounds of Formula I and the pharmaceutically acceptable salts of the compounds, including the isomers, are also disclosed. The compounds (including the isomers thereof) and salts of the invention exhibit anti-tumor, anti-psoriatic and anti-inflammatory activities.

US Patent:

61774766, Jan 23, 2001

Filed:

Aug 27, 1998

Appl. No.:

9/141061

Inventors:

Andrew C. Peterson - Madison WI
Thaddeus P. Pruss - Madison WI

Assignee:

Clarion Pharmaceuticals Inc. - Madison WI

International Classification:

A61K 3108

US Classification:

514722

Abstract:

A method of replenishing plasmalogens in mammals comprising treatment with a plasmalogen-replenishing-effective amount of one or more stantially pure monoethers of glycerols and their carboxylic acid ester derivatives of Formula I: ##STR1## wherein R is a C. sub. 12 -C. sub. 22 linear or branched alkyl or alkenyl group; and R. sup. 1 and R. sup. 2 are, each independently, hydrogen or an acyl moiety {--C(. dbd. O)--R. sup. 3 } wherein R. sup. 3 is a linear or branched C. sub. 1 -C. sub. 30 alkyl or alkenyl; and pharmaceutically-acceptable salts thereof, is disclosed. Nutritional supplements, dietary supplements and food additives comprising one or more substantially pure compounds of Formula I is also disclosed.

US Patent:

57769150, Jul 7, 1998

Filed:

Aug 12, 1997

Appl. No.:

8/910191

Inventors:

Andrew C. Peterson - Madison WI
Haridasan K. Nair - Williamsville NY

Assignee:

Clarion Pharmaceuticals Inc. - Madison WI

International Classification:

A61K 31685
A61K 9127
C07F 910
C07F 909

US Classification:

514 77

Abstract:

Novel retinoid phosphocholines are disclosed having the general Formula (I): ##STR1## wherein R represents a retinyl or retinoyl moiety. The optical and geometric isomers of compounds of Formula (I) and the pharmaceutically-acceptable salts thereof, are also disclosed. The subject compounds exhibit anti-tumor, anti-psoriatic and anti-inflammatory activities in addition to their inherent Vitamin A-like activities. The invention embraces the novel compounds, pharmaceutical compositions thereof, and methods of using the same.

US Patent:

56913281, Nov 25, 1997

Filed:

Aug 27, 1996

Appl. No.:

8/703447

Inventors:

Andrew C. Peterson - Madison WI
Parvin T. Yazdi - Madison WI

Assignee:

Clarion Pharmaceuticals Inc. - Madison WI

International Classification:

A61K 3159
C07C40100

US Classification:

514167

Abstract:

Certain phosphoethanolamine conjugates of vitamin D compounds are disclosed wherein the phosphoethanolamine moiety is bonded at the 3-position of the vitamin D moiety. The conjugates exhibit anti-tumor, anti-psoriatic and anti-inflammatory activities in addition to those activities associated with vitamin D. The invention embraces the novel compounds, pharmaceutical compositions thereof, and their methods of use.