Yuriy Dunayevskiy - Natick MA, US Dallas Hughes - Milford MA, US Andrew Weiskopf - Needham MA, US
International Classification:
G01N033/53
US Classification:
435/007100
Abstract:
The invention encompasses an improved, rapid, size-exclusive method for screening for small molecular weight ligands that bind specifically to a protein target, using size-exclusion separation, ultrafiltration, and mass spectrometry.
Jianxin Chen - Littleton MA, US Gerhard Sperl - Salem NH, US Vincent Gullo - Basking Ridge NJ, US Lalitha Sista - Moula Ali, IN Dallas Hughes - Milford MA, US Yucai Peng - Shrewsbury MA, US William Pierceall - Sudbury MA, US Andrew Weiskopf - Needham MA, US Jeremy Levin - New City NY, US Russell Dushin - Garrison NY, US Mercy Otteng - Pearl River NY, US
Sulfamoyl-containing compounds are disclosed, having utility as inhibitors of disease-related targets, such as Heat Shock Protein 90 (HSP90), and which are useful for treating disorders, e.g., proliferative disorders, including HSP90-mediated disorders. Methods for preparing and using the disclosed compounds are also described.