University Pennsylvania Lung 3400 Civic Center Blvd, Philadelphia, PA 19104 2156623202 (Phone)
Certifications:
Critical Care Medicine, 2004 Internal Medicine, 1999 Pulmonary Disease, 2003
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
University Pennsylvania Lung 3400 Civic Center Blvd, Philadelphia, PA 19104
Presbyterian Hospital 1100 Central Avenue South East, Albuquerque, NM 87106
Hospital of the University of Pennsylvania 3400 Spruce Street, Philadelphia, PA 19104
Education:
Medical School University Of California, San Francisco, School Of Medicine Graduated: 1996 Medical School University Pa Graduated: 1997 Medical School University Pa Graduated: 1999
Internal Medicine Critical Care Medicine Pulmonary Disease Critical Care Medicine
Work:
Philadelphia Veterans Affairs Medical Center
3900 Woodland Ave, Philadelphia, PA 19104 Penn. Lung Center
3400 Civic Center Blvd, Philadelphia, PA 19104
Education:
University of California at San Francisco (1996)
License Records
Anil Vachani
Address:
Merion Station, PA 19066
License #:
MD066508L - Active
Category:
Medicine
Type:
Medical Physician and Surgeon
Us Patents
Method For Diagnosing Lung Cancers Using Gene Expression Profiles In Peripheral Blood Mononuclear Cells
Michael Showe - Media PA, US Louise Showe - Media PA, US Malik Yousef - Dabburiya Village, IL Steven M. Albelda - Bala Cynwyd PA, US Anil Vachani - Merion Station PA, US Andrei V. Kossenkov - Huntingdon Valley PA, US
Assignee:
The Wistar Institute of Anatomy and Biology - Philadelphia PA The Trustees of the University of Pennsylvania - Philadelphia PA
Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected genes, e. g. , a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile. Another composition for similar use contains a plurality of polynucleotides immobilized on a substrate, which probes hybridize to three or more gene expression products from genes in the gene expression profile. Still another composition involves detection of the protein expression products of genes from the gene expression profile.
Method For Distinguishing Between Head And Neck Squamous Cell Carcinoma And Lung Squamous Cell Carcinoma
Louise Showe - Media PA, US Anil Vachani - Merion Station PA, US Steven Albelda - Bala Cynwyd PA, US
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be used to distinguish between primary squamous cell carcinoma of the lung and metastatic head and neck squamous cell carcinoma. These genes include CXCL13, COL6A2, SFTPB, KRT14, TSPYL5, TMP3, KLK10, MMP1, GAS1, and MYH2. A panel of one or more of these genes, or proteins encoded thereby, can be used for early diagnosis and selection of an appropriate therapeutic treatment.
Method For Diagnosing Lung Cancers Using Gene Expression Profiles In Peripheral Blood Mononuclear Cells
Malik Yousef - Dabburiya Village, IL Steven M. Albelda - Bala Cynwyd PA, US Anil Vachani - Merion Station PA, US Andrei V. Kossenkov - Huntingdon Valley PA, US
International Classification:
C12Q 1/68
US Classification:
506 9, 506 16, 506 18
Abstract:
Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile. Another composition for similar use contains a plurality of polynucleotides immobilized on a substrate, which probes hybridize to three or more gene expression products from genes in the gene expression profile. Still another composition involves detection of the protein expression products of genes from the gene expression profile.
Method For Diagnosing Lung Cancers Using Gene Expression Profiles In Peripheral Blood Mononuclear Cells
- Philadelphia PA, US Malik Yousef - Dabburiya Village, IL Steven M. Albelda - Bala Cynwyd PA, US Anil Vachani - Merion Station PA, US Andrei V. Kossenkov - Huntingdon Valley PA, US
International Classification:
G01N 33/574 C12Q 1/6886
Abstract:
Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile. Another composition for similar use contains a plurality of polynucleotides immobilized on a substrate, which probes hybridize to three or more gene expression products from genes in the gene expression profile. Still another composition involves detection of the protein expression products of genes from the gene expression profile.
Method For Diagnosing Lung Cancers Using Gene Expression Profiles In Peripheral Blood Mononuclear Cells
- Philadelphia PA, US Malik Yousef - Dabburiya Village, IL Steven M. Albelda - Bala Cynwyd PA, US Anil Vachani - Merion Station PA, US Andrei V. Kossenkov - Huntingdon Valley PA, US
International Classification:
G01N 33/574 C12Q 1/68
Abstract:
Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile. Another composition for similar use contains a plurality of polynucleotides immobilized on a substrate, which probes hybridize to three or more gene expression products from genes in the gene expression profile. Still another composition involves detection of the protein expression products of genes from the gene expression profile.
Youtube
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