Anil Kumar Vuppu

US Patent:

7344301, Mar 18, 2008

Filed:

Dec 14, 2004

Appl. No.:

11/011521

Inventors:

Antonio A. Garcia - Chandler AZ, US
Anil K. Vuppu - Phoenix AZ, US

Assignee:

Arizona Board of Regents - Tempe AZ

International Classification:

B01F 13/08

US Classification:

366273

Abstract:

This invention provides a device and method for rotating magnetically inducible particles suspended in a fluid by rotating a multidirectional magnetic field through the suspended particles. A rare earth magnet is positioned adjacent to the suspended particles and oriented such that the axis of a magnetic field generated by the magnet passes through the suspension. The magnetic flux lines of the magnet's field radiate in multiple directions through the suspended particles, them to form long multidirectional chains. The magnet and the chains of suspended particles are rotated with respect to one another, the axis of the rotation being approximately parallel to the magnetic axis of the multidirectional magnetic field. This causes the particle chains to rotate about the magnetic axis, thus mixing the fluid.

US Patent:

20040126903, Jul 1, 2004

Filed:

Aug 1, 2003

Appl. No.:

10/633352

Inventors:

Antonio Garcia - Chandler AZ, US
Mark Hayes - Gilbert AZ, US
Anil Vuppu - Tempe AZ, US
Karl Booksh - Gilbert AZ, US

International Classification:

G01N033/553

US Classification:

436/526000

Abstract:

A method for measuring low levels of a substance in a sample includes the formation of a rotor from paramagnetic particles in a substantially uniform magnetic field. The rotor is rotated by rotating the substantially uniform magnetic field. A portion of the substance in a sample is bound to the paramagnetic particles, and a signal having a time-varying component is detected. The signal is then processed using a lock-in amplifier with a reference signal having a frequency twice that of the rotation of the magnetic field. This improves the signal-to-noise ratio of the time-varying component of the signal.

US Patent:

20050032051, Feb 10, 2005

Filed:

Jun 19, 2001

Appl. No.:

10/296489

Inventors:

Mark Hayes - Tempe AZ, US
Nolan Polson - Longmont CO, US
Anil Vuppu - Tempe AZ, US
Timothy Crowley - Tempe AZ, US
Antonio Garcia - Tempe AZ, US

International Classification:

C12Q001/68
C12M001/34

US Classification:

435006000, 435287200

Abstract:

A microimmunoassay arrangement including paramagnetic particles having labeled antibody held in a microchannel by an external magnetic field provides rapid analysis using small sample volumes.