Ann M English

US Patent:

20130259883, Oct 3, 2013

Filed:

May 24, 2011

Appl. No.:

13/699563

Inventors:

Donald F. Hunt - Charlottesville VA, US
Jeffrey Shabanowitz - Charlottesville VA, US
Jennifer Cottine - Charlottesville VA, US
Ann M. English - Palmyra VA, US
Andrew Norris - Palmyra VA, US
Victor H. Engelhard - Crozet VA, US
Mark Cobbold - Birmingham, GB
Kara L. Cummings - Charlottesville VA, US
Angela Zarling - Charlottesville VA, US
Rebecca C. Obeng - Cambridge MA, US
Jie Qian - Somerset NJ, US

Assignee:

PHOSIMMUNE, INC. - Charlottesville VA

International Classification:

C07K 7/06
C07K 16/18
G01N 33/68
C07K 7/08
A61K 39/00

US Classification:

4241851, 530328, 530327, 436501, 5303879, 435377, 435325, 435 792, 435 723

Abstract:

A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.

US Patent:

20230059301, Feb 23, 2023

Filed:

Jul 8, 2022

Appl. No.:

17/811546

Inventors:

- Lexington MA, US
- Norman OK, US
Ann Michelle English - Palmyra VA, US
Jeffrey Shabanowitz - Charlottesville VA, US
William H. Hildebrand - Edmond OK, US
Oriana E. Hawkins - Tuscola TX, US

International Classification:

C07K 7/08
C07K 14/47
A61K 39/00
C07K 7/06
C07K 16/18

Abstract:

The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.

US Patent:

20200399312, Dec 24, 2020

Filed:

Mar 2, 2020

Appl. No.:

16/806374

Inventors:

- Lexington MA, US
- Norman OK, US
Ann Michelle ENGLISH - Palmyra VA, US
Jeffrey SHABANOWITZ - Charlottesville VA, US
William H. HILDERBRAND - Edmond OK, US
Oriana E. HAWKINS - Tuscola TX, US

International Classification:

C07K 7/08
C07K 14/47
A61K 39/00
C07K 7/06
C07K 16/18

Abstract:

The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.

US Patent:

20180066017, Mar 8, 2018

Filed:

Apr 10, 2017

Appl. No.:

15/483274

Inventors:

- Lexington MA, US
Jeffrey Shabanowitz - Charlottesville VA, US
Jennifer Cottine - Charlottesville VA, US
Ann M. English - Palmyra VA, US
Andrew Norris - Palmyra VA, US
Victor H. Engelhard - Crozet VA, US
Mark Cobbold - Birmingham, GB
Kara L. Cummings - Charlottesville VA, US
Angela Zarling - Charlottesville VA, US
Rebecca C. Obeng - Charlottesville VA, US
Jie Qian - Somerset NJ, US

International Classification:

C07K 7/06
G01N 33/68
C07K 16/18
C07K 7/08
A61K 39/00

Abstract:

A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.

US Patent:

20150225456, Aug 13, 2015

Filed:

May 28, 2013

Appl. No.:

14/403350

Inventors:

- Charlottesville VA, US
- Norman OK, US
Ann Michelle English - Palmyra VA, US
Jeffrey Shabanowitz - Charlottesville VA, US
William H. Hilderbrand - Edmond OK, US
Oriana E. Hawkins - Tuscola TX, US

International Classification:

C07K 7/08
A61K 39/00
C07K 16/18
C07K 7/06

Abstract:

The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.