Ann Cam Hoang

US Patent:

6905886, Jun 14, 2005

Filed:

Mar 13, 2002

Appl. No.:

10/099498

Inventors:

Lata Sundaram - Laguna Niguel CA, US
Ann Hoang - Lake Forest CA, US
Stan Shimizu - Trabuco Canyon CA, US
Elizabeth R. Umelo-Njaka - Trabuco Canyon CA, US
Darcy A. Thomas - Lake Forest CA, US

Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE

International Classification:

G01N033/546
G01N033/533
G01N033/534

US Classification:

436534, 436 15, 436 18, 436526, 436545, 436546, 436804, 436817, 436826

Abstract:

This invention relates to preservative solutions for peptides, for example, parathyroid hormone, insulin-like growth factor binding protein 3 (IGFBP3), adrenocorticotropic hormone (ACTH) and mixtures thereof. Preferably, the peptides preserved by the solutions are non-reconstituted. In one embodiment, the preservative solutions comprise a polyvinyl alcohol, EDTA component and molybdic component.

US Patent:

6387711, May 14, 2002

Filed:

Aug 11, 2000

Appl. No.:

09/637649

Inventors:

Lata Sundaram - Laguna Niguel CA
Ann Hoang - Lake Forest CA
Stan Shimizu - Trabuco Canyon CA

Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE

International Classification:

G01N 33546

US Classification:

436534, 436526, 436804, 436817

Abstract:

A solution of a non-reconstituted hormone and a preservative having a useful shelf life of at least six months, and, in some circumstances, at least a year. A series of solution of varying levels of the non-reconstituted hormone may be in a test kit and used in a process to determine the level of the hormone in a patient sample. In an aspect of the invention, the hormone is parathyroid hormone. The preservatives may be polyvinyl alcohol, a dissolved EDTA salt, or dissolved sodium molybdate. The hormone may be in an aqueous or a buffered matrix containing very little protein and substantial amounts of TX100 to reduce non-specific binding. The solution is incubated with a solid phase coated with an anti-hormone antibody and a labeled hormone antibody. The solid phase is read using a suitable device for measuring the labeled hormone antibody. An example of a labeled hormone antibody is an acridinium labeled hormone antibody that is read using a light reading device.