Ann Marie Simpson

US Patent:

20200276100, Sep 3, 2020

Filed:

Oct 8, 2019

Appl. No.:

16/596409

Inventors:

Michael Einziger - Malibu CA, US
Ann Marie Simpson - Malibu CA, US

International Classification:

A61K 8/49
A61Q 17/04

Abstract:

Compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. -derived compounds and/or chemical analogs thereof, compositions that comprise such compounds, and methods of treating by administering the compounds and compositions, including methods of inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, and melanin concentration.

US Patent:

20200060952, Feb 27, 2020

Filed:

Aug 23, 2019

Appl. No.:

16/549106

Inventors:

Michael Einziger - Malibu CA, US
Ann Marie Simpson - Malibu CA, US

International Classification:

A61K 8/49
A61P 17/16
A61Q 17/04
A61Q 19/02
A61K 31/404
A61K 31/407
A61K 31/519

Abstract:

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve -derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

US Patent:

20190381004, Dec 19, 2019

Filed:

Jun 14, 2019

Appl. No.:

16/441522

Inventors:

Michael Einziger - Malibu CA, US
Ann Marie Simpson - Malibu CA, US

International Classification:

A61K 31/40
A61K 8/49
A61K 9/00
A61Q 19/02
A61Q 19/08
A61Q 17/04
A61P 17/16
A61K 9/12

Abstract:

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve -derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

US Patent:

20190345140, Nov 14, 2019

Filed:

Apr 12, 2019

Appl. No.:

16/382891

Inventors:

Michael Einziger - Malibu CA, US
Ann Marie Simpson - Malibu CA, US

International Classification:

C07D 403/06
C07D 405/06
C07D 487/04
C07D 519/00
A61K 31/404
A61K 31/407
A61K 31/55
A61K 8/49
A61Q 19/02

Abstract:

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve -derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

US Patent:

20190337927, Nov 7, 2019

Filed:

May 7, 2019

Appl. No.:

16/405127

Inventors:

Michael Einziger - Malibu CA, US
Ann Marie Simpson - Malibu CA, US

International Classification:

C07D 403/04
A61K 8/49
A61Q 19/02

Abstract:

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve -derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating aylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

US Patent:

20180370913, Dec 27, 2018

Filed:

Sep 4, 2018

Appl. No.:

16/121353

Inventors:

Michael Einziger - Malibu CA, US
Ann Marie Simpson - Malibu CA, US

International Classification:

C07D 209/12
C07D 487/04
A61K 8/49
A61Q 19/02

Abstract:

The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.

US Patent:

20180329670, Nov 15, 2018

Filed:

May 14, 2018

Appl. No.:

15/978726

Inventors:

- Santa Monica CA, US
Ann Marie Simpson - Santa Monica CA, US
Darren LaGroe - Westlake Village CA, US

International Classification:

G06F 3/16
H04W 4/06
H04L 29/06

Abstract:

A method of delivering audio to one or more client computing devices includes receiving, by an audio server computing device, a live audio signal starting at a first time; processing, by the audio server computing device, the live audio signal, thereby creating a data representation of the live audio signal; transmitting, by the audio server computing device, via a wireless network in electronic communication with the audio server computing device, the data representation of the live audio signal to the one or more client computing devices; interpreting, by the one or more client computing devices, the data representation of the live audio signal, thereby producing an interpreted audio signal; and providing, by the one or more client computing devices, the interpreted audio signal to a user listening device starting at a second time. A latency between the first time and the second time is less than 100 milliseconds.

US Patent:

20180329671, Nov 15, 2018

Filed:

May 14, 2018

Appl. No.:

15/978754

Inventors:

- Santa Monica CA, US
Ann Marie Simpson - Santa Monica CA, US
Nathanial Pollack - San Francisco CA, US
Vikram Singh - Los Altos Hills CA, US

International Classification:

G06F 3/16
H04W 4/02
H04L 29/06

Abstract:

A computerized method of delivering data to one or more client computing devices includes receiving, by a server computing device, a data stream starting at a first time; processing, by the server computing device, the data stream, thereby creating a processed data stream; transmitting, by the server computing device, via a wireless network in electronic communication with the server computing device, the processed data stream to the one or more client computing devices; and interpreting, by an application installed on the one or more client computing devices, the processed data stream, thereby recovering the data stream for use by the one or more client computing devices. A latency between the first time and the second time is less than 100 milliseconds.