It has been discovered that TRPC5 activity abolishes actin stress fibers and diminishes focal adhesion formation, rendering a motile, migratory podocyte phenotype. This invention relates generally to methods of reducing expression or activity of TRPC5 to treat, or reduce risk of developing, kidney disease, e.g., proteinuria, in a subject.
Compositions And Methods Related To Di-Substituted Bicyclo[2.2.1] Heptanamine-Containing Compounds
Brigham & Womens Hospital Renal 75 Francis St, Boston, MA 02115 6177326383 (phone), 6179750840 (fax)
Education:
Medical School Harvard Medical School Graduated: 2004
Procedures:
Dialysis Procedures
Conditions:
Acute Renal Failure Calculus of the Urinary System Chronic Renal Disease Cirrhosis Hypertension (HTN)
Languages:
Chinese English
Description:
Dr. Greka graduated from the Harvard Medical School in 2004. She works in Boston, MA and specializes in Nephrology. Dr. Greka is affiliated with Brigham & Womens Hospital.
165 Cambridge St, Boston, MA 02114 55 Fruit St, Boston, MA 02114
Education:
Doctor of Medicine Massachusetts General Hospital - Fellowship - Nephrology (Internal Medicine) Massachusetts General Hospital - Residency - Internal Medicine Massachusetts General Hospital - Internship - Internal Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine American Board of Internal Medicine Sub-certificate in Nephrology (Internal Medicine)