Anne Hodges Evans

US Patent:

8394354, Mar 12, 2013

Filed:

May 8, 2007

Appl. No.:

12/300000

Inventors:

Lisa A. Paige - Hillsborough NC, US
Matthew W. Mitchell - Durham NC, US
Anne Evans - Durham NC, US
Don Harvan - Durham NC, US
David Carl Steffens - Durham NC, US
K. Ranga R. Krishnan - Chapel Hill NC, US

Assignee:

Metabolon, Inc. - Durham NC
Duke University - Durham NC

International Classification:

G01N 33/49
G01N 33/50
G01N 33/64

US Classification:

424 91, 702 19, 702 23

Abstract:

The present invention provides various biomarkers of depression. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of depression, methods of determining predisposition to depression, methods of monitoring progression/regression of depression, methods of assessing efficacy of compositions for treating depression, methods of screening compositions for activity in modulating biomarkers of depression, methods of treating depression, as well as other methods based on biomarkers of depression.

US Patent:

20070298998, Dec 27, 2007

Filed:

Feb 27, 2007

Appl. No.:

11/711518

Inventors:

Lisa Paige - Hillsborough NC, US
Matthew Mitchell - Durham NC, US
Anne Evans - Durham NC, US
Don Harvan - Durham NC, US
Kay Lawton - Raleigh NC, US
Robert Brown - Needham MA, US
Merit Cudkowicz - Newton MA, US

Assignee:

Metabolon, Inc. - Durham NC

International Classification:

A61K 38/00
A61P 25/28
G01N 30/02

US Classification:

514002000, 436161000

Abstract:

The present invention provides various biomarkers of amyotrophic lateral sclerosis (ALS). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of determining predisposition to ALS, methods of monitoring progression/regression of ALS, methods of assessing efficacy of compositions for treating ALS, methods of screening compositions for activity in modulating biomarkers of ALS, methods of treating ALS, as well as other methods based on biomarkers of ALS.

US Patent:

20090179147, Jul 16, 2009

Filed:

Dec 3, 2008

Appl. No.:

12/327758

Inventors:

K. Eric Milgram - Limerick PA, US
Thomas Barrett - Raleigh NC, US
Anne M. Evans - Durham NC, US

International Classification:

B01D 59/44
H01J 49/00
G01N 30/00

US Classification:

250282, 250281, 73 6152

Abstract:

Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition of chemical constituents in a complex mixture includes generating, using a separation tool and a mass spectrometer, separation and mass spectrometry data of a sample, wherein the separation data includes peak information and wherein the mass spectrometry data includes primary and secondary mass spectrometry data. The analysis results, including the generated separation and mass spectrometry data, are collected and stored. A chemical constituent of the sample is determined by comparing the analysis results to a library of information indicating characteristics of chemical entities, where the comparison is based on the separation and mass spectrometry information. The library of information includes data generated by the separation tool and mass spectrometer, and also includes separation and mass spectrometry data for both identified and unidentified chemical entities. An indication of the chemical constituent of the sample is made available in human-accessible form.

US Patent:

20090318369, Dec 24, 2009

Filed:

Aug 15, 2008

Appl. No.:

12/192469

Inventors:

Lisa A. Paige - Hillsborough NC, US
Matthew W. Mitchell - Durham NC, US
Anne Evans - Durham NC, US
Don Harvan - Durham NC, US

International Classification:

A61K 31/70
G01N 33/50
G01N 33/92
G01N 33/53
C12Q 1/02
G01N 33/68
A61K 31/195
A61K 31/56
A61K 31/19
A61K 31/415
A61K 31/52
A61K 31/66
A61P 25/28

US Classification:

514 23, 436111, 436 71, 436129, 436 96, 436 98, 436 93, 436103, 436 94, 435 792, 435 29, 436 86, 514563, 514182, 514557, 514396, 5142631, 514 75

Abstract:

The present invention provides various biomarkers of Alzheimer's Disease (AD). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of AD, methods of determining predisposition to AD, methods of monitoring progression/regression of AD, methods of assessing efficacy of compositions for treating AD, methods of screening compositions for activity in modulating biomarkers of AD, methods of treating AD, as well as other methods based on biomarkers of AD.

US Patent:

20220221433, Jul 14, 2022

Filed:

May 8, 2020

Appl. No.:

17/611639

Inventors:

- Morrisville NC, US
Anne M. EVANS - Cary NC, US
Elizaveta FREINKMAN - Cary NC, US

International Classification:

G01N 30/72
G01N 30/06

Abstract:

A method for determining in a sample, by liquid chromatography/mass spectrometry, the presence, absence, or amount of one or more or a plurality of analytes is described. The method comprises subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the one or more of the analytes; measuring, by liquid chromatography/mass spectrometry, the amount of the one or more ions from each of the one or more analytes; and using the measured amount of the one or more ions to determine the presence, absence, or amount of each of the one or more or plurality of analytes in the sample.

US Patent:

20200110069, Apr 9, 2020

Filed:

Oct 14, 2019

Appl. No.:

16/601198

Inventors:

- Morrisville NC, US
Klaus Peter Adam - Cary NC, US
Michael V. Milburn - Cary NC, US
Jeffery E. Cobb - Chapel Hill NC, US
Anne M. Evans - Cary NC, US
Qibo Zhang - Cary NC, US

International Classification:

G01N 33/50
C07K 16/44
C07D 307/33
A61K 31/341
A61K 31/137
A61K 31/7048
A61K 31/4439
A61K 31/155
A61K 31/485
G01N 33/68

Abstract:

The present invention provides a method for diagnosing a disease or disorder selected from the group consisting of insulin resistance, a metabolic disorder, diabetes and pre-diabetes in a subject. The method comprises the step of determining the level of a compound represented by structural formula (VI):or a salt thereof. Compositions and method of making thereof are also described.

US Patent:

20200033360, Jan 30, 2020

Filed:

Mar 28, 2018

Appl. No.:

16/491471

Inventors:

- Morrisville NC, US
Anne M. EVANS - Cary NC, US
Kelli GOODMAN - Raleigh NC, US
Richard J. ROBINSON - Morrisville NC, US

International Classification:

G01N 33/68
G01N 33/92

Abstract:

A method for determining in a sample, by mass spectrometry, the presence, absence or amount of one or more lipid species from one or more lipid classes is described herein. The one or more lipid classes are selected from the group consisting of wax esters (WE), squalene (SQ), triacylglycerols (TAG), diacylglycerols (DAG), free fatty acids (FFA), cholesteryl esters (CE), cholesterol (CH), and combinations thereof. The method includes a) subjecting the sample to an ionization source to produce one or more ions detectable by mass spectrometry from each of the one or more lipid species; b) measuring, by mass spectrometry, the amount of the one or more ions from each of the one or more lipid species; and c) using the measured amount of the one or more ions to determine the presence, absence or amount of each of the one or more lipid species.

US Patent:

20190152907, May 23, 2019

Filed:

Jul 27, 2017

Appl. No.:

16/321135

Inventors:

- Morrisville NC, US
Anne M. Evans - Cary NC, US

International Classification:

C07D 207/16
C07B 59/00
G01N 33/53

Abstract:

The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.