Anne W Evans

US Patent:

20220221433, Jul 14, 2022

Filed:

May 8, 2020

Appl. No.:

17/611639

Inventors:

- Morrisville NC, US
Anne M. EVANS - Cary NC, US
Elizaveta FREINKMAN - Cary NC, US

International Classification:

G01N 30/72
G01N 30/06

Abstract:

A method for determining in a sample, by liquid chromatography/mass spectrometry, the presence, absence, or amount of one or more or a plurality of analytes is described. The method comprises subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the one or more of the analytes; measuring, by liquid chromatography/mass spectrometry, the amount of the one or more ions from each of the one or more analytes; and using the measured amount of the one or more ions to determine the presence, absence, or amount of each of the one or more or plurality of analytes in the sample.

US Patent:

20200110069, Apr 9, 2020

Filed:

Oct 14, 2019

Appl. No.:

16/601198

Inventors:

- Morrisville NC, US
Klaus Peter Adam - Cary NC, US
Michael V. Milburn - Cary NC, US
Jeffery E. Cobb - Chapel Hill NC, US
Anne M. Evans - Cary NC, US
Qibo Zhang - Cary NC, US

International Classification:

G01N 33/50
C07K 16/44
C07D 307/33
A61K 31/341
A61K 31/137
A61K 31/7048
A61K 31/4439
A61K 31/155
A61K 31/485
G01N 33/68

Abstract:

The present invention provides a method for diagnosing a disease or disorder selected from the group consisting of insulin resistance, a metabolic disorder, diabetes and pre-diabetes in a subject. The method comprises the step of determining the level of a compound represented by structural formula (VI):or a salt thereof. Compositions and method of making thereof are also described.

US Patent:

20200033360, Jan 30, 2020

Filed:

Mar 28, 2018

Appl. No.:

16/491471

Inventors:

- Morrisville NC, US
Anne M. EVANS - Cary NC, US
Kelli GOODMAN - Raleigh NC, US
Richard J. ROBINSON - Morrisville NC, US

International Classification:

G01N 33/68
G01N 33/92

Abstract:

A method for determining in a sample, by mass spectrometry, the presence, absence or amount of one or more lipid species from one or more lipid classes is described herein. The one or more lipid classes are selected from the group consisting of wax esters (WE), squalene (SQ), triacylglycerols (TAG), diacylglycerols (DAG), free fatty acids (FFA), cholesteryl esters (CE), cholesterol (CH), and combinations thereof. The method includes a) subjecting the sample to an ionization source to produce one or more ions detectable by mass spectrometry from each of the one or more lipid species; b) measuring, by mass spectrometry, the amount of the one or more ions from each of the one or more lipid species; and c) using the measured amount of the one or more ions to determine the presence, absence or amount of each of the one or more lipid species.

US Patent:

20190152907, May 23, 2019

Filed:

Jul 27, 2017

Appl. No.:

16/321135

Inventors:

- Morrisville NC, US
Anne M. Evans - Cary NC, US

International Classification:

C07D 207/16
C07B 59/00
G01N 33/53

Abstract:

The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.

US Patent:

20180031541, Feb 1, 2018

Filed:

Feb 4, 2016

Appl. No.:

15/548854

Inventors:

- Morrisville NC, US
Klaus Peter Adam - Cary NC, US
Michael V. Milburn - Cary NC, US
Jeffery E. Cobb - Chapel Hill NC, US
Anne M. Evans - Cary NC, US
Qibo Zhang - Cary NC, US

International Classification:

G01N 33/50
C07K 16/44
C07D 307/33

Abstract:

The present invention provides a method for diagnosing a disease or disorder selected from the group consisting of insulin resistance, a metabolic disorder, diabetes and pre-diabetes in a subject. The method comprises the step of determining the level of a compound represented by structural formula (VI): or a salt thereof. Compositions and method of making thereof are also described.