A rat ganglioside GM -specific 1â2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM -specific 1â2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM -specific 1â2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM -specific 1â2fucosyltransferase and derivatives and analogs thereof (e. g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM -specific 1â2fucosyltransferase (e. g. by means of antisense RNA) are provided. Methods of commercial scale use of the rat ganglioside GM -specific 1â2fucosyltransferase in the production of fucosyl-saccharide compositions are described.
Nucleic Acids And Proteins Of A Rat Ganglioside Gm1-Specific Α1-2Fucosyltransferase And Uses Thereof
A rat ganglioside GM-specific α1→2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM-specific α1→2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM-specific α1→2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM-specific α1→2fucosyltransferase and derivatives and analogs thereof (e. g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM-specific α1→2fucosyltransferase (e. g. by means of antisense RNA) are provided. Methods of commercial scale use of the rat ganglioside GM-specific α1→2fucosyltransferase in the production of fucosyl-saccharide compositions are described.
Reflex Supplemental Testing - A Rapid, Efficient And Highly Accurate Method To Identify Subjects With An Infection, Disease Or Other Condition
Lawrence Green - Redmond WA, US Anne Sherwood - Kirkland WA, US
International Classification:
G01N 33/554 G01N 33/569
US Classification:
435007320
Abstract:
The present disclosure concerns methods, compositions and apparatus for detecting pathogens and/or molecular markers. In a particular embodiment, the pathogen to be detected may be or any other species that causes in a mammal. However, the disclosed methods are not limited and virtually any type of pathogen and/or molecular marker may be screened and detected. Preferred embodiments comprise reflex supplemental testing using the same assay at approximately 100% sensitivity and the highest possible corresponding sensitivity—in one example 70%. Such assay conditions, used iteratively, result in elimination of 70% of uninfected subjects for each round of testing. Use of 4 or more rounds of testing results in less than 1% error. Since only positive samples are retested, the methods provide a rapid, inexpensive and highly accurate way to detect infected subjects.
Nucleic Acids And Proteins Of A Rat Ganglioside Gm1-Specific Alpha1-2Fucosyltransferase And Uses Thereof
A rat ganglioside GM-specific α1→2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM-specific α1→2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM-specific α1→2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM-specific α1→2fucosyltransferase and derivatives and analogs thereof (e.g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM-specific α1→2fucosyltransferase (e.g. by means of antisense RNA) are provided. Methods of commercial scale use of the rat ganglioside GM-specific α1→2fucosyltransferase in the production of fucosyl-saccharide compositions are described. Applications of these compositions, e.g. as additives for human nutritive compositions or immunotherapeutics for cancer, are disclosed.
Compositions And Methods Of Testing For Tuberculosis And Mycobacterium Infection
Lawrence R. Green - Tacoma WA, US Anne L. Sherwood - Kirkland WA, US
Assignee:
PRITEST, INC - Redmond WA
International Classification:
G01N 33/53
US Classification:
435 71
Abstract:
The present disclosure concerns methods, compositions and apparatus for detecting pathogens and/or molecular markers. In a particular embodiment, the pathogen to be detected may be or any other species that causes tuberculosis in a mammal. However, the disclosed methods are not limited and virtually any type of pathogen and/or molecular marker may be screened and detected. Preferred embodiments comprise reflex supplemental testing using the same assay at approximately 100% sensitivity and the highest possible corresponding sensitivity—in one example 70%. Such assay conditions, used iteratively, result in elimination of 70% of uninfected subjects for each round of testing. Use of 4 or more rounds of testing results in less than 1% error. Since only positive samples are retested, the methods provide a rapid, inexpensive and highly accurate way to detect infected subjects.
Nucleic Acids And Proteins Of A Rat Ganglioside Gm1-Specific .Alpha.1.Fwdarw.2Fucosyltransferase And Uses Thereof
Eric H. Holmes - Bothell WA Anne L. Sherwood - Mountlake Terrace WA
Assignee:
Northwest Hospital - Seattle WA
International Classification:
C07H 2104 C07H 2102 C12P 2106 C12N 100 C12N 500
US Classification:
435 691
Abstract:
A rat ganglioside GM. sub. 1 -specific. alpha. 1. fwdarw. 2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM. sub. 1 -specific. alpha. 1. fwdarw. 2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM. sub. 1 -specific. alpha. 1. fwdarw. 2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM. sub. 1 -specific. alpha. 1. fwdarw. 2fucosyltransferase and derivatives and analogs thereof (e. g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM. sub. 1 -specific. alpha. 1. fwdarw. 2fucosyltransferase (e. g.
Born in Corner Brook, Newfoundland now married to David and live in Dieppe New Brunswick have 2 children Tara & John and 4 step children. 11 grandchildren