Anne Noble Smith

US Patent:

7157446, Jan 2, 2007

Filed:

Apr 20, 2004

Appl. No.:

10/827952

Inventors:

Anne Marie Smith - Glen Gardner NJ, US
Michael Cucolo - Basking Ridge NJ, US
Munir N. Nassar - Skillman NJ, US

Assignee:

Bristol Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/724
A61K 31/715

US Classification:

514 58, 514 54, 514221, 514970, 514973, 536103

Abstract:

A ras-farnesyltransferase inhibitor complex formed from a ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, a substituted cyclodextrin, and ethanol is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor, improved dissolution, enhanced stability and is essentially free of particulate matter.

US Patent:

60313765, Feb 29, 2000

Filed:

Feb 19, 1997

Appl. No.:

8/802631

Inventors:

Angelo Gallotti - Milan, IT
Christoph De Haen - Milan, IT
Anne Marie Smith - Glen Gardner NJ
Michael N. Eakins - East Windsor NJ
Julius P. Zodda - Mercerville NJ

Assignee:

Dibra S.p.A. - Milan

International Classification:

G01V 300

US Classification:

324309

Abstract:

Devices, and a method for the use thereof, for the standardization of signal intensity in the formation of magnetic resonance images of the human body, said devices including one or more straight, bent or flexible closed tubes with an external diameter not greater than 3 cm, an internal diameter of not less than 0. 2 cm and a length of not less than 8 cm, made of susbtantially diamagnetic material, other than glass, preferably a plastic material, particularly polyvinyl chloride, each of them being filled with aqueous solutions or gels containing paramagnetic components, said tubes being kept close to the body either by means of the positioning devices of the body to which they are fixed permanently or temporarily, or by fixings which, on one side, can be fixed to the human body and on the other keep the tubes in the required positior.