Annette K Lewis

US Patent:

6862561, Mar 1, 2005

Filed:

May 22, 2002

Appl. No.:

10/154123

Inventors:

Nadine A. Defranoux - San Francisco CA, US
Todd B. Dubnicoff - Burlingame CA, US
Annette K. Lewis - Menlo Park CA, US
Thomas S. Paterson - West Hollywood CA, US
Saroja Ramanujan - San Mateo CA, US
Lisl K. M. Shoda - Redwood City CA, US
Karl Petter Soderstrom - San Francisco CA, US
Herbert K. Struemper - Menlo Park CA, US

Assignee:

Entelos, Inc. - Foster City CA

International Classification:

G06G007/48
G06F017/10

US Classification:

703 11, 703 2

Abstract:

The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.

US Patent:

7472050, Dec 30, 2008

Filed:

Feb 11, 2005

Appl. No.:

11/056952

Inventors:

Nadine A. Defranoux - San Francisco CA, US
Todd B. Dubnicoff - Burlingame CA, US
Annette K. Lewis - Menlo Park CA, US
Thomas S. Paterson - West Hollywood CA, US
Saroja Ramanujan - San Mateo CA, US
Lisl K. M. Shoda - Redwood City CA, US
Karl Petter Soderstrom - San Francisco CA, US
Herbert K. Struemper - Menlo Park CA, US

Assignee:

Entelos, Inc. - Foster City CA

International Classification:

G06G 7/48

US Classification:

703 11, 703 2

Abstract:

The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.

US Patent:

20030104475, Jun 5, 2003

Filed:

Jun 28, 2002

Appl. No.:

10/186938

Inventors:

Scott Kelly - Champaign IL, US
David Klinke - San Bruno CA, US
Clement Leong - Erskineville, AU
Annette Lewis - Menlo Park CA, US
Miles Okino - Belmont CA, US
Thomas Paterson - West Hollywood CA, US
Lisl Shoda - Redwood City CA, US
Cynthia Stokes - Menlo Park CA, US
Herbert Struemper - Menlo Park CA, US

International Classification:

G01N033/53
G01N033/50

US Classification:

435/007100, 435/004000, 702/019000

Abstract:

The present invention relates generally to a computer model of an adaptive immune response. One embodiment of the invention relates to a computer model of an adaptive immune response within the framework of signals conveyed at the site of antigen exposure. Another embodiment of the model includes a representation of complex physiological regulatory mechanisms related to, for example, cellular dynamics, mediator production, antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte activation, lymphocyte trafficking, and/or lymphocyte effector function. In another embodiment, the model can account for mediator production in response to antigen within a chronically inflamed peripheral tissue, as well as the regulatory effects of mediators on APC and lymphocyte population dynamics, including maturation, activation, and apoptosis, and the regulatory effects of mediators produced by APCs and lymphocytes on a chronically inflamed peripheral tissue. Another embodiment of the invention relates to an analytical model of an adaptive immune response.

US Patent:

20080201122, Aug 21, 2008

Filed:

Oct 4, 2007

Appl. No.:

11/867658

Inventors:

Scott D. Kelly - Champaign IL, US
David J. Klinke - San Bruno CA, US
Clement Leong - Erskineville, AU
Annette K. Lewis - Menlo Park CA, US
Miles S. Okino - Belmont CA, US
Thomas S. Paterson - Redondo Beach CA, US
Lisl K.M. Shoda - Redwood City CA, US
Cynthia Stokes - Menlo Park CA, US
Herbert K. Struemper - Menlo Park CA, US

International Classification:

G06G 7/60

US Classification:

703 11

Abstract:

The present invention relates generally to a computer model of an adaptive immune response. One embodiment of the invention relates to a computer model of an adaptive immune response within the framework of signals conveyed at the site of antigen exposure. Another embodiment of the model includes a representation of complex physiological regulatory mechanisms related to, for example, cellular dynamics, mediator production, antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte activation, lymphocyte trafficking, and/or lymphocyte effector function. In another embodiment, the model can account for mediator production in response to antigen within a chronically inflamed peripheral tissue, as well as the regulatory effects of mediators on APC and lymphocyte population dynamics, including maturation, activation, and apoptosis, and the regulatory effects of mediators produced by APCs and lymphocytes on a chronically inflamed peripheral tissue. Another embodiment of the invention relates to an analytical model of an adaptive immune response.

US Patent:

49219529, May 1, 1990

Filed:

Apr 20, 1989

Appl. No.:

7/341281

Inventors:

Jonathan L. Longmire - Los Alamos NM
Annette K. Lewis - La Jolla CA
Carl E. Hildebrand - Los Alamos NM

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

C07H 2100
C07H 2102
C07H 2104

US Classification:

536 27

Abstract:

A method is provided for isolating DNA from eukaryotic cell and flow sorted chromosomes. When DNA is removed from chromosome and cell structure, detergent and proteolytic digestion products remain with the DNA. These products can be removed with organic extraction, but the process steps associated with organic extraction reduce the size of DNA fragments available for experimental use. The present process removes the waste products by dialyzing a solution containing the DNA against a solution containing polyethylene glycol (PEG). The waste products dialyze into the PEG leaving isolated DNA. The remaining DNA has been prepared with fragments containing more than 160 kb. The isolated DNA has been used in conventional protocols without affect on the protocol.

US Patent:

44743742, Oct 2, 1984

Filed:

Oct 26, 1978

Appl. No.:

5/954913

Inventors:

Dwayne K. Lewis - Santa Clara CA
Annette H. Lewis - Santa Clara CA

International Classification:

A63D 1500

US Classification:

273 5R

Abstract:

A game table for playing Chinese billiards includes a first or basic playing surface provided by a member of square configuration having a Masonite veneer surface thereon. This relatively hard playing surface is bounded on all sides by an upwardly projecting rail, and is provided with suitable holes and with lines and other indicia scribed thereon so that the game can be played using wooden pucks. When the game is being played, the table is supported on a tripod stand. A second playing surface is provided in the form of a removable insert made up of a flat, square sheet of stiff material covered with a felt cloth on which the same indicia is marked. The felt surface makes it possible to play the same game using plastic or hard rubber balls. The insert fits snugly inside the rails of the basic board and is provided with holes that correspond in location to the holes in the basic board.