Anthony M Allison

US Patent:

20090291086, Nov 26, 2009

Filed:

May 21, 2009

Appl. No.:

12/470381

Inventors:

ANTHONY ALLISON - MOUNTAIN VIEW CA, US

Assignee:

ALAVITA PHARMACEUTICALS, INC. - MOUNTAIN VIEW CA

International Classification:

A61K 39/395
A61K 38/17
A61P 7/00

US Classification:

4241411, 514 12, 4241751

Abstract:

Modified annexin proteins, including heterodimers and homodimer of various human annexins, are provided for treatment of cerebral thrombosis and global cerebral ischemia. Also provided are phosphatidylserine (PS) binding proteins for treatment of cerebral thrombosis and global cerebral ischemia. The modified annexins and/or PS binding proteins bind PS on cell surfaces, thereby preventing the attachment of leukocytes and platelets to endothelial cells during post-ischemic reperfusion. By maintaining endothelial cell and vascular wall integrity PS binding proteins and/or modified annexin proteins decrease cerebral hemorrhage. Modified annexins and other PS binding proteins also suppress the production of mediators of edema, the extension of cerebral damage during reperfusion and the risk of rethrombosis. Thus, modified annexin proteins and/or other PS binding proteins decrease brain damage following cerebral thrombosis and global cerebral ischemia.