Anthony John Downing

US Patent:

7422574, Sep 9, 2008

Filed:

Feb 25, 2003

Appl. No.:

10/374853

Inventors:

Elof Eriksson - Wellesley MA, US
Christian Baker - Weymouth MA, US
W. Robert Allison - Sudbury MA, US
Tom Johnson - Milford NH, US
Anthony Downing - Ayer MA, US
Denis Labombard - Georgetown MA, US
John Navickas - Norfolk MA, US
Patrick Guiney - Concord MA, US

Assignee:

Applied Tissue Technologies, LLC - Wellesley MA

International Classification:

A61M 5/00

US Classification:

604264

Abstract:

An apparatus is provided to enable the direct gene transfer of genetic material into a target cell site (“microseeding”), as a means of obtaining long term expression of native or non-native polypeptides in a host. The apparatus includes a matrix of microneedles that oscillate at a predetermined frequency and receive the genetic material from a delivery system that is integrated with the apparatus.

US Patent:

20070276356, Nov 29, 2007

Filed:

Jun 29, 2005

Appl. No.:

11/629724

Inventors:

Anthony Downing - Ayer MA, US
James Wilkie - Melrose MA, US
Ronald Court - Pelham NH, US
Steven Jacques - Westford MA, US
Michael Gauderer - Greenville SC, US

Assignee:

C. R. BARD, INC. - Murray Hill NJ

International Classification:

A61M 25/16

US Classification:

604535000

Abstract:

A low profile adaptor is disclosed to reduce the length of a gastrostomy tube that has been inserted by means of conventional endoscopic procedures or with a replacement feeding tube inserted into the patient's stomach. The gastrostomy tube is cut to the appropriate length by the physician. The adaptor comprises a stem which is inserted into the open end of the gastrostomy tube. The valve assembly contains a seal that functions as a one-way valve to prevent reflux of gastric contents but permits the introduction of feeding solution into the feeding tube. A lock and key mechanism is incorporated into the hub of the gastrostomy tube to prevent disconnection of the feeding tube. A cover is placed over the opening of the adapter to prevent contamination of the lumen of the gastrostomy tube.