Kent E. Goklen - King of Prussia PA, US Eric J. Suda - Phoenixville PA, US Antonio Raul Ubiera - King of Prussia PA, US
Assignee:
GLAXOSMITHKLINE LLC - Philadelphia PA
International Classification:
C07K 1/18
US Classification:
530416, 2524081
Abstract:
The invention is directed to a method for producing a polypeptide composition comprising: combining a polypeptide with a volatile additive to form a liquid mixture and lyophilizing the liquid mixture to obtain a lyophilized polypeptide composition.
A method for purifying a protein using a simplified, sodium chloride-free buffer system that consists of two components (acid and base pairs) for appropriate solution pH control; and a third component for ionic strength control, where the third component is the sodium salt conjugate base.
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