April E Carpenter

US Patent:

20120309818, Dec 6, 2012

Filed:

Jan 20, 2012

Appl. No.:

13/355256

Inventors:

Jonathan Steven ALEXANDER - Shreveport LA, US
April C. Carpenter - Cincinnati OH, US
Trevor Percival Castor - Arlington MA, US

International Classification:

A61K 31/365
C07D 493/22
A61P 29/00

US Classification:

514453, 549267

Abstract:

Embodiments of the present invention feature methods for treating inflammatory disease and transplantation characterized in that it includes: (i) the incubation of organs with one or more Bryostatin-1 derivatives under conditions which permits vascular exposure to these compounds prior to or immediately following organ ‘harvesting’, and (ii) intravenous, transdermal, intraperitoneal, intra-alveolar instillation of Bryostatin-1 in vivo during active disease, or during periods of disease remission and (iii) prophylactic administration of Bryostatin-1 to limit the development of GVHD.