Arthur L Brown

US Patent:

6391561, May 21, 2002

Filed:

Nov 14, 2000

Appl. No.:

09/712495

Inventors:

Arthur M. Brown - Brecksville OH
Barbara A. Wible - Cleveland OH
Qing Yang - S. Euclid OH

Assignee:

The MetroHealth System - Cleveland OH

International Classification:

C12Q 168

US Classification:

435 6, 435 71, 435 911, 435 912, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 530350

Abstract:

The present invention provides polynucleotides that encode a protein, designated herein as K+ Channel Associated Protein or âKChAPâ. It has been determined that expressing polynucleotides that encode KChAP in host cells, along with polynucleotides that encode the Kv channel subunit Kv 2. 1, the Kv channel subunit Kv 2. 2, the Kv channel subunit Kv 1. 3, or the Kv channel subunit Kv 4. 3, increases the number of Kv2. 1, Kv 2. 2, Kv1. 3 or Kv4. 3 channels, respectively, in the plasma membrane of such cells. The present invention also relates to a method of making cells that have increased numbers of Kv channels on the plasma membranes thereof and to a method of using such cells as model systems for studying the effect of pharmacological agents on Kv channels, particularly on Kv2. 1, Kv 2. 2, Kv 1. 3, and Kv 4. 3 channels.

US Patent:

6743797, Jun 1, 2004

Filed:

Feb 22, 2002

Appl. No.:

10/079485

Inventors:

Arthur M. Brown - Brecksville OH
Naresh Chand - Gaithersburg MD

Assignee:

ChanTest, Inc. - Cleveland OH
United States of America - Washington DC

International Classification:

A61K 31495

US Classification:

51425504

Abstract:

Disclosed are methods of preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof, such as a human, an effective amount of vanoxerine (GBR 12909) or a pharmaceutically acceptable salt, derivative or metabolite thereof.

US Patent:

7060794, Jun 13, 2006

Filed:

Feb 13, 2002

Appl. No.:

10/075074

Inventors:

Arthur M Brown - Brecksville OH, US
Barbara A Wible - Cleveland OH, US
Qing Yang - S. Euclid OH, US

Assignee:

The MetroHealth System - Cleveland OH

International Classification:

C07K 14/00

US Classification:

530350

Abstract:

The present invention provides polynucleotides that encode a protein, designated herein as K+ Channel Associated Protein or “KChAP”. It has been determined that expressing polynucleotides that encode KChAP in host cells, along with polynucleotides that encode the Kvα channel subunit Kv 2. 1, the Kvα channel subunit Kv 2. 2, the Kvα channel subunit Kv 1. 3, or the Kvα channel subunit Kv 4. 3, increases the number of Kv2. 1, Kv 2. 2, Kv1. 3 or Kv4. 3 channels, respectively, in the plasma membrane of such cells. The present invention also relates to a method of making cells that have increased numbers of Kv channels on the plasma membranes thereof and to a method of using such cells as model systems for studying the effect of pharmacological agents on Kv channels, particularly on Kv2. 1, Kv 2. 2, Kv 1. 3, and Kv 4. 3 channels.

US Patent:

7211407, May 1, 2007

Filed:

Aug 6, 2003

Appl. No.:

10/635010

Inventors:

Arthur M. Brown - Brecksville OH, US
Eckhard Ficker - Cleveland OH, US
Barbara A. Wible - Cleveland OH, US

Assignee:

Chan Test, Inc. - Cleveland OH

International Classification:

G01N 33/53

US Classification:

435 721, 435 723, 435 724, 435 29

Abstract:

Disclosed are high throughput assay systems and methods for identifying agents that alter the level of surface expression of integral membrane proteins, such as cardiac ion channels, in mammalian cells. Also disclosed are therapeutic methods of using agents identified using such methods.

US Patent:

7678548, Mar 16, 2010

Filed:

Jul 8, 2008

Appl. No.:

12/216579

Inventors:

Arthur M. Brown - Brecksville OH, US
Eckhard Ficker - Cleveland OH, US
Barbara A. Wible - Cleveland OH, US

Assignee:

ChanTest, Inc. - Cleveland OH

International Classification:

G01N 33/53

US Classification:

435 721, 435 723, 435 724, 435 79, 435366, 435375, 436 15, 436 55, 436 56, 436 63, 436 64, 436517, 436546

Abstract:

Disclosed are high throughput assay systems and methods for identifying agents that alter the level of expression of proteins in mammalian cells, particularly integral membrane proteins.

US Patent:

7700600, Apr 20, 2010

Filed:

Jul 25, 2007

Appl. No.:

11/878611

Inventors:

Arthur M. Brown - Brecksville OH, US
Naresh Chand - Gaithersburg MD, US

Assignee:

ChanTest, Inc. - Cleveland OH
United States of America - Washington DC

International Classification:

A61K 31/496

US Classification:

51425504

Abstract:

Disclosed are methods of preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof, such as a human, an effective amount of vanoxerine (GBR 12909) or a pharmaceutically acceptable salt, derivative or metabolite thereof.

US Patent:

8187586, May 29, 2012

Filed:

Feb 23, 2004

Appl. No.:

10/784528

Inventors:

Arthur M. Brown - Brecksville OH, US
Barbara A. Wible - Cleveland OH, US

Assignee:

Case Western Reserve University - Cleveland OH

International Classification:

A01N 63/00
A01N 65/00
A61K 48/00
C12N 15/00

US Classification:

424 932, 424 931, 424 936, 4353201

Abstract:

Methods of inducing apoptosis in hyperproliferative cells, particularly cancer cells are provided. Such method involves increasing the levels of a potassium channel modulatory protein in the cell. Examples of such proteins are native KChAP protein, a biologically active variant of native KChAP protein, or a biologically active KChAP-related protein (collectively referred to hereinafter as “KChAP protein”). In one embodiment, the cells are contacted with the KChAP protein under conditions permitting uptake of the protein by the cells. In another embodiment, the cells are contacted with (i) a nucleic acid encoding the KChAP protein, and (ii) a promoter active in the cancer cell, wherein the promoter is operably linked to the region encoding the KChAP protein, under conditions permitting the uptake of the nucleic acid by the cancer cell. Methods of detecting cancerous cells in a biological sample selected from the group consisting of a colorectal tissue sample or brain tissue sample are also provided. Such method comprises assaying for the presence of elevated levels of KChAP mRNA or KChAP protein in the sample.

US Patent:

8450325, May 28, 2013

Filed:

Jun 13, 2011

Appl. No.:

13/158791

Inventors:

Arthur M. Brown - Brecksville OH, US
Naresh Chand - Gaithersburg MD, US

Assignee:

ChanRx Corp. - Cleveland OH
The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC

International Classification:

A61K 31/4965

US Classification:

51425504

Abstract:

Disclosed are methods of preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof, such as a human, an effective amount of vanoxerine (GBR 12909) or a pharmaceutically acceptable salt, derivative or metabolite thereof.

Address:

856 Rutherford Dr, Jackson, MS 39206

VIN:

5FNYF3H54BB009713

Make:

HONDA

Model:

PILOT

Year:

2011

Address:

5 Sherwood Ct, Beachwood, OH 44122

Phone:

2162927736

VIN:

2T2HK31U77C009399

Make:

LEXUS

Model:

RX 350

Year:

2007