Arthur Haas

US Patent:

20160201049, Jul 14, 2016

Filed:

Mar 31, 2016

Appl. No.:

15/086719

Inventors:

Arthur L. Haas - New Orleans LA, US
Virginia P. Ronchi - New Orleans LA, US

Assignee:

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

International Classification:

C12N 9/00

Abstract:

Methods are provided for modulating the activity of multimeric ubiquitin-protein E3 ligases including, but not limited to, E6AP ligase activities. The methods reduce the level of oligomer formation such as homotrimeric E6AP ligase to reduce the enzyme activity. Alternatively, agents are provided that can promote the association of the ligase monomers, thereby increasing the ligase activity. Accordingly, novel therapeutic strategies are provided that are useful for the treatment of pathologies resulting from mutations in the genes encoding the ligases and which adversely increase or decrease a ubiquitination reaction.

US Patent:

20150210998, Jul 30, 2015

Filed:

Apr 14, 2015

Appl. No.:

14/685865

Inventors:

Arthur L. Haas - New Orleans LA, US
Virginia P. Ronchi - New Orleans LA, US

Assignee:

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

International Classification:

C12N 9/99

Abstract:

Methods are provided for modulating the activity of multimeric ubiquitin-protein E3 ligases including, but not limited to, E6AP ligase activities. The methods reduce the level of oligomer formation such as homotrimeric E6AP ligase to reduce the enzyme activity. Alternatively, agents are provided that can promote the association of the ligase monomers, thereby increasing the ligase activity. Accordingly, novel therapeutic strategies are provided that are useful for the treatment of pathologies resulting from mutations in the genes encoding the ligases and which adversely increase or decrease a ubiquitination reaction.