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- Philadelphia PA, US Arthur Howe - Philadelphia PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA Imvax, Inc. - Philadelphia PA
International Classification:
A61K 47/68 C07K 16/28 C07K 16/30
Abstract:
The present disclosure provides methods and compositions for enhancing the treatment of a cancer, particularly in a human subject, by administering antibody drug conjugates (ADCs) to inhibit or kill specific myeloid/monocyte/macrophage-lineage cells. The myeloid/monocyte/macrophage-lineage cells are identified, for example, by expression of one or more of the scavenger receptors CD204 and CD163, and/or mannose receptor-1 (CD206).
Arthur Howe (1919-1923), Howard Slade (1940-1952), Robert Montmoran (1944-1948), Arthur Luke (1951-1955), Charles Underwood (1927-1939), Darrell Smith (1935-1947)
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