Andrew Siwkowski - Carlsbad CA, US Edward Wancewicz - Poway CA, US Thomas Leedom - Fallbrook CA, US Lynnetta Watts - Carlsbad CA, US Mausumee Guha - Carlsbad CA, US Brett Monia - Encinitas CA, US Richard Griffey - Vista CA, US Richard Geary - Carlsbad CA, US Scott Henry - Cardiff by the Sea CA, US Arthur Levin - Rancho Santa Fe CA, US
International Classification:
A61K 31/7088 A61P 3/00 A61P 3/10 C07H 21/00
US Classification:
514044000, 536023100
Abstract:
The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes PTEN, SGLT2 and connective tissue growth factor (CTGF) in the kidney.
Prevention And Treatment Of Premalignant Epithelial Lesions And Malignant Tumors Of Epithelial Origin
Werner Bollag - Basel, CH Joseph F. Grippo - Basking Ridge NJ Arthur Levin - Glen Ridge NJ
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 3120
US Classification:
514559
Abstract:
The compound 9-cis-retinoic acid, its pharmaceutically acceptable salts or its pharmaceutically acceptable esters can be used in the treatment of precancerous or premalignant epithelial lesions as well as in the treatment of malignant tumors of an epithelial nature.
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