Arthur D Rosen

US Patent:

6552173, Apr 22, 2003

Filed:

Nov 27, 2001

Appl. No.:

09/995203

Inventors:

Lakshman R. Sehgal - Flossmoor IL
Richard E. De Woskin - Mount Prospect IL
Gerald S. Moss - Highland Park IL
Steven A. Gould - Highland Park IL
Arthur L. Rosen - Wilmette IL
Hansa Sehgal - Flossmoor IL

Assignee:

Northfield Laboratories, Inc. - Evanston IL

International Classification:

A61K 3714

US Classification:

530385, 514 6, 514832, 424529

Abstract:

An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.

US Patent:

6914127, Jul 5, 2005

Filed:

Jan 21, 2003

Appl. No.:

10/348579

Inventors:

Lakshman R. Sehgal - Flossmoor IL, US
Richard E. De Woskin - Mount Prospect IL, US
Gerald S. Moss - Highland Park IL, US
Steven A. Gould - Highland Park IL, US
Arthur L. Rosen - Wilmette IL, US
Hansa Sehgal - Flossmoor IL, US

International Classification:

A61K037/14

US Classification:

530385, 514 6, 514832, 424529

Abstract:

An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.

US Patent:

57476497, May 5, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/484942

Inventors:

Lakshman R. Sehgal - Flossmoor IL
Richard E. De Woskin - Mount Prospect IL
Gerald S. Moss - Highland Park IL
Steven A. Gould - Highland Park IL
Arthur L. Rosen - Wilmette IL
Hansa Sehgal - Flossmoor IL

Assignee:

Norhtfield Laboratories, Inc. - Evanston IL

International Classification:

A61K 3514

US Classification:

530385

Abstract:

An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.

US Patent:

52176487, Jun 8, 1993

Filed:

Oct 11, 1991

Appl. No.:

7/776062

Inventors:

Richard L. Beissinger - Oak Park IL
Darsh T. Wasan - Darien IL
Lakshman R. Sehgal - Glenview IL
Arthur L. Rosen - Wilmette IL

Assignee:

Illinois Institute of Technology - Chicago IL
Northfield Laboratories, Inc. - Evanston IL

International Classification:

A61K 9113
A61K 3714
B01J 1300

US Classification:

252314

Abstract:

A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.

US Patent:

50616889, Oct 29, 1991

Filed:

Aug 19, 1988

Appl. No.:

7/234386

Inventors:

Richard L. Beissinger - Oak Park IL
Darsh T. Wasan - Westmont IL
Arthur L. Rosen - Wilmette IL

Assignee:

Illinois Institute of Technology - Chicago IL
Northfield Laboratories, Inc. - Evanston IL

International Classification:

A61K 9113
A61K 3714
B01J 1300

US Classification:

514 6

Abstract:

A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute. A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsions while maintaining high yields and high oxygen exchange activity.

US Patent:

54648149, Nov 7, 1995

Filed:

Feb 28, 1994

Appl. No.:

8/203505

Inventors:

Lakshman R. Sehgal - Flossmoor IL
Richard E. De Woskin - Mount Prospect IL
Gerald S. Moss - Highland Park IL
Steven A. Gould - Highland Park IL
Arthur L. Rosen - Wilmette IL
Hansa Sehgal - Flossmoor IL

Assignee:

Northfield Laboratories, Inc. - Evanston IL

International Classification:

A61K 3714

US Classification:

514 6

Abstract:

A process is disclosed for the preparation of an essentially tetramer-free, essentially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin which comprises separating red blood cell stroma from blood by means of heat treating step to remove stromal contaminants and filtration or centrifugation or both, pyridoxylating, polymerizing, and removing essentially all of the remaining unmodified tetramer.

US Patent:

54380413, Aug 1, 1995

Filed:

Mar 3, 1993

Appl. No.:

8/025608

Inventors:

Shuming Zheng - Chicago IL
Richard L. Beissinger - Oak Park IL
Darsh T. Wasan - Darien IL
Lakshman R. Sehgal - Glenview IL
Arthur L. Rosen - Wilmette IL

Assignee:

Illinois Institute of Technology - Chicago IL
Northfield Laboratories, Inc. - Evanston IL

International Classification:

A61K 9113
A61K 3714
B01J 1300

US Classification:

514 6

Abstract:

A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.