Dipeptidylpeptidase IV inhibitor (herein referred to as DPP-IV) that may be 98.5-100% pure is a high-dose drug capable of being directly compressed with specific excipients into sold form dosage forms, such as tablets and capsules having desired, hardness, disintegrating ability and acceptable dissolution characteristics. DPP-IV is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow DPP-IV to be compressed using the direct compression method. The tablets produced provide an acceptable in vitro dissolution profile.
James Kowalski - Belle Mead NJ, US Jay Parthiban Lakshman - Cedar Knolls NJ, US Arun Patel - Succasunna NJ, US
International Classification:
A61K 9/20 A61K 31/4439 A61K 9/14 A61K 31/40
US Classification:
424465, 514342, 514423, 424464, 424489
Abstract:
Dipeptidylpeptidase IV inhibitor (herein referred to as DPP-IV) that may be 98.5-100% pure is a high-dose drug capable of being directly compressed with a glitazone and specific excipients into sold form dosage forms, such as tablets and capsules having desired, hardness, disintegrating ability and acceptable dissolution characteristics. DPP-IV is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow DPP-IV to be compressed using the direct compression method. The tablets produced provide an acceptable in vitro dissolution profile.
James Kowalski - Belle Mead NJ, US Jay Parthiban LakShman - Cedar Knolls NJ, US Arun P. Patel - Succasunna NJ, US
Assignee:
Novartis AG - Basel
International Classification:
A61K 9/20 A61K 31/40 C07D 207/16
US Classification:
424464, 548528, 514423
Abstract:
Dipeptidylpeptidase IV inhibitor (herein referred to as DPP-IV) that may be 98.5-100% pure is a high-dose drug capable of direct compressed with specific excipients into sold form dosage forms, such as tablets and capsules having desired, hardness, disintegrating ability and acceptable dissolution characteristics. DPP-IV is not inherently compressible and thus present formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow DPP-IV to be compressed using the direct compression method. The tablets produced provide an acceptable in vitro dissolution profile.
Feb 2013 to 2000 ABAP developmentSAP PI/ABAP Maplewood, MN Mar 2013 to May 2014 Technical expertise in project management support tools HP Quality Center, Clear QuestL'Oreal Berkeley Heights, NJ Oct 2012 to Mar 2013 Lead for WEB based interfacesCintas Cincinnati, OH Jul 2012 to Oct 2012GE Health Care Princeton, NJ Apr 2012 to Jul 2012 Interface ManagerL3 Com Salt Lake City, UT Sep 2011 to Apr 2012 Sr SAP PI consultant - Assisting L3Grainger Lake Forest, IL Oct 2010 to Aug 2011 Sr SAP XI/PI Consultant - AssistingHubWoo LLP Chicago, IL Mar 2010 to Oct 2010 Sr SAP XI/PI Integration Lead - HubwooDefense Logistic Agency
Apr 2009 to Mar 2010 EhP1 Architect/Subject Matter Expert - Interfaced SRMRaytheon Dallas, TX Jun 2006 to Mar 2009 SAP Sr. Technical/Architect Consultant - Interfaced SAPZLB Behring King of Prussia, PA Mar 2006 to Jun 2006 SAP Sr. Technical ConsultantComputer Science Corporation Morristown, NJ Aug 2005 to Dec 2005 SAP Sr. Technical ConsultantLockheed Martin Maritime Systems & Sensors Morristown, NJ Apr 2004 to Aug 2005 SAP Sr. Technical ConsultantPicking and Packing King of Prussia, PA Mar 2004 to Apr 2004 SAP Sr. Technical ConsultantKonica Minolta
Feb 2004 to Mar 2004 SAP Sr. Technical Consultant - ArchitectEmphasis
2004 to 2004 Development ConsultantAventis Pasteur Swiftwater, PA Sep 2003 to Dec 2003 SAP Sr. Technical ConsultantDOPACO Inc Downingtown, PA May 2003 to Sep 2003 SAP Sr. Technical ConsultantWest Pharmaceutical Lionville, PA Sep 2002 to Nov 2002 SAP Sr. Technical ConsultantLDS Inc
Oct 2002 to Oct 2002 SAP HR ITS/ESS Specialist - Feasibility StudySAP America Newtown, PA Oct 2000 to Oct 2001 Sr. Technical Consultant
Education:
Penn State University Mar 2003 to May 2003 Certificate in Architecture and AdministrationWest Chester University Master's in Project Management
Mar 2012 to Present PharmacistDuane Reade Corporation New York, NY 2004 to 2012 Director of Pharmacy AdministrationDuane Reade Corporation New York, NY 2002 to 2004 Director of Pharmacy OperationsDuane Reade Corporation New York, NY 1994 to 2002 Pharmacy District ManagerDuane Reade Corporation New York, NY 1990 to 1994 Pharmacy ManagerBoots UK and Independent Pharmacies London 1983 to 1989 Pharmacist
2003 to 2000 Division Sales Manager (Part-Time)New York Institute of Technology New York, NY 2003 to 2004 Computer Services Technician (Part-Time)Liberty Science Center Jersey City, NJ 2002 to 2003 Hospitality Associate (Part-Time)
Education:
New York Institute of Technology New York, NY 2008 BA in Computer and Electrical Engineering
Mercy Saint Vincent Specialty Clinic 2213 Cherry St FL 2 STE 200 ACC, Toledo, OH 43608 4192514283 (phone), 4192513271 (fax)
Education:
Medical School Univ of Glasgow Fac of Med, Glasgow, Scotland (919 05 Eff 1/1971) Graduated: 1963
Procedures:
Arthrocentesis Carpal Tunnel Decompression Hip/Femur Fractures and Dislocations Joint Arthroscopy Knee Arthroscopy Lower Arm/Elbow/Wrist Fractures and Dislocations Lower Leg/Ankle Fractures and Dislocations Hallux Valgus Repair Hip Replacement Knee Replacement Lower Leg Amputation Shoulder Arthroscopy Shoulder Surgery Spinal Surgery Wound Care
Conditions:
Fractures, Dislocations, Derangement, and Sprains Hallux Valgus Internal Derangement of Knee Internal Derangement of Knee Cartilage Internal Derangement of Knee Ligaments
Languages:
Arabic English Spanish
Description:
Dr. Patel graduated from the Univ of Glasgow Fac of Med, Glasgow, Scotland (919 05 Eff 1/1971) in 1963. He works in Toledo, OH and 1 other location and specializes in Orthopaedic Surgery. Dr. Patel is affiliated with Mercy Medical Center, Mercy St Anne Hospital, Mercy St Charles Hospital, Mercy St Vincent Medical Center, Promedica Flower Hospital and Toledo Hospital.
Dr. Patel graduated from the L Tilak Mun Med Coll, Mumbai Univ, Mumbai, Maharashtra, India in 1976. He works in Salamanca, NY and specializes in Family Medicine and Internal Medicine - Geriatrics. Dr. Patel is affiliated with Olean General Hospital.
Dr. Patel graduated from the Johns Hopkins University School of Medicine in 1982. He works in Elk Grove, CA and 6 other locations and specializes in Ophthalmology. Dr. Patel is affiliated with Dignity Health Mercy General Hospital, Dignity Health Saint Josephs Medical Center and Doctors Medical Center Modesto.
Dr. Patel graduated from the Inst of Med Sci, Banaras Hindu Univ, Varanasi, Up, India in 1982. He works in Fullerton, CA and specializes in Internal Medicine. Dr. Patel is affiliated with Anaheim Regional Medical Center and Saint Jude Medical Center.
Christina Ioannou, Karen Hinton, Kathy Quinerly, Perry King, James Mcaleenan, Linda Caldwell, Hal Watkins, Diane Nation, B Davis, Wail Jaber, Patty Evans