Ashok Gupta

US Patent:

20130309250, Nov 21, 2013

Filed:

May 13, 2013

Appl. No.:

13/892671

Inventors:

Stacie M. Goldberg - Princeton NJ, US
Ashok K. Gupta - Plainsboro NJ, US
Xi Tao Wang - Wellesley MA, US
John M. Wigginton - Collegeville PA, US

International Classification:

C07K 16/28

US Classification:

4241721, 5303882

Abstract:

The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

US Patent:

20160257750, Sep 8, 2016

Filed:

Nov 5, 2014

Appl. No.:

15/032919

Inventors:

- Princeton NJ, US
- Marseille, FR
Cecile BONNAFOUS - Marseille, FR
Ashok K. GUPTA - Plainsboro NJ, US
Luisa M. SALTER-CID - Princeton Junction NJ, US
Michael Darron ROBBINS - Hillsborough NJ, US

International Classification:

C07K 16/28
A61K 9/00
A61K 39/395

Abstract:

Provided are methods for clinical treatment of multiple myeloma using an anti-KIR antibody in combination with an anti-CS 1 antibody.