Atsuo T Kuki

US Patent:

6613942, Sep 2, 2003

Filed:

Dec 23, 1998

Appl. No.:

09/220003

Inventors:

Anthony Ling - San Diego CA
Vlad Gregor - Del Mar CA
Javier Gonzalez - Oceanside CA
Yufeng Hong - San Diego CA
Dan Kiel - San Diego CA
Atsuo Kuki - Encinitas CA
Shenghua Shi - San Diego CA
Lars Naerum - Hellerup, DK
Peter Madsen - Bagsvaerd, DK
Christian Sams - Frederiksberg, DK
Jesper Lau - Farum, DK
Michael Bruno Plewe - La Jolla CA
Jun Feng - La Mesa CA
Min Teng - San Diego CA
Michael David Johnson - San Diego CA
Kimberly Ann Teston - San Diego CA
Ulla Grove Sidelmann - Vedbaek, DK
Lotte Bjerre Knudsen - Valby, DK

Assignee:

Novo Nordisk A/S - Bagsvaerd

International Classification:

C07C23300

US Classification:

564161, 564251, 514482, 514488, 514647, 514651

Abstract:

Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.

US Patent:

7001912, Feb 21, 2006

Filed:

Jan 26, 2004

Appl. No.:

10/765227

Inventors:

Atsuo Kuki - Encinitas CA, US
Xinqiang Li - San Diego CA, US
Michael Bruno Plewe - San Diego CA, US
Hai Wang - San Diego CA, US
Junhu Zhang - San Diego CA, US

Assignee:

Agouron Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/437
C07D 471/02
C07D 471/12

US Classification:

514293, 514287, 546 64, 546 87

Abstract:

Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.

US Patent:

7135482, Nov 14, 2006

Filed:

Oct 30, 2003

Appl. No.:

10/699068

Inventors:

Qiyue Hu - San Diego CA, US
Ted William Johnson - San Diego CA, US
Atsuo Kuki - Encinitas CA, US
Michael Bruno Plewe - San Diego CA, US
Dawn Marie Nowlin - San Diego CA, US
Hai Wang - San Diego CA, US
Junhu Zhang - San Diego CA, US

Assignee:

Agouron Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/44

US Classification:

514300, 546113, 546118, 514303

Abstract:

Bicyclic hydroxamate compounds represented by the Formula I:.

US Patent:

7138408, Nov 21, 2006

Filed:

Oct 14, 2005

Appl. No.:

11/251344

Inventors:

Atsuo Kuki - Encinitas CA, US
Xinqiang Li - San Diego CA, US
Michael Bruno Plewe - San Diego CA, US
Hai Wang - San Diego CA, US
Junhu Zhang - San Diego CA, US

Assignee:

Agouron Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/437
C07D 471/12

US Classification:

514287, 546 64, 540521, 514215

Abstract:

Beta-carboline hydroxamic acid compounds represented by formula (I).

US Patent:

7368571, May 6, 2008

Filed:

Sep 6, 2006

Appl. No.:

11/470301

Inventors:

Qiyue Hu - Carlsbad CA, US
Atsuo Kuki - Encinitas CA, US
Dawn Marie Nowlin - San Diego CA, US
Michael Bruno Plewe - San Diego CA, US
Hai Wang - San Diego CA, US
Junhu Zhang - San Diego CA, US

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D 471/02
C07D 471/00

US Classification:

546113, 546118

Abstract:

Bicycling hydroxamate compounds represented by the Formula I:.

US Patent:

20040039044, Feb 26, 2004

Filed:

Apr 29, 2003

Appl. No.:

10/415546

Inventors:

Yuanjin Rui - San Diego CA, US
Atsuo Kuki - Encinitas CA, US
Yufeng Hong - San Diego CA, US
Zhengwei Peng - San Diego CA, US
David Luthin - Encinitas CA, US

International Classification:

A61K031/40
A61K031/4025
C 07D 4 9/02
C 07D 4 5/02

US Classification:

514/408000, 514/422000, 548/525000, 548/528000, 548/566000

Abstract:

Novel aminoalkylpyrrolidine 5-HTreceptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treating sleep disorders, pain, depression, and schizophrenia employing the receptor ligands are disclosed. The receptor ligands have formula (1): wherein the formula variables are as defined herein, and pharmaceutically acceptable salts, solvates, active metabolites, or prodrugs thereof.

US Patent:

20040044037, Mar 4, 2004

Filed:

Apr 29, 2003

Appl. No.:

10/415619

Inventors:

Yufeng Hong - San Diego CA, US
Atsuo Kuki - Encinitas CA, US
Eileen Tompkins - Escondido CA, US
Zhengwei Peng - San Diego CA, US
David Luthin - Encinitas CA, US

International Classification:

A61K031/445
A61K031/401
A61K031/165
C07C279/20

US Classification:

514/317000, 514/423000, 514/613000, 546/226000, 548/530000, 564/147000

Abstract:

Novel amidino-urea 5-HTreceptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treating sleep disorders, pain, depression, and schizophrenia employing the receptor ligands are disclosed. The receptor ligands have formula (1): wherein the formula variables are as defined herein, and pharmaceutically acceptable salts, solvates, active metabolites, or prodrugs thereof.

US Patent:

20060063932, Mar 23, 2006

Filed:

Sep 19, 2005

Appl. No.:

11/229816

Inventors:

Yuanjin Rui - San Diego CA, US
Atsuo Kuki - Encinitas CA, US
Yufeng Hong - San Diego CA, US
Zhengwei Peng - San Diego CA, US
David Luthin - Encinitas CA, US

International Classification:

A61K 31/4025
C07D 409/02
C07D 405/02

US Classification:

546183000, 548517000, 548527000, 548528000, 548561000

Abstract:

Novel aminoalkylpyrrolidine 5-HTreceptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treating sleep disorders, pain, depression, and schizophrenia employing the receptor ligands are disclosed. The receptor ligands have formula (1): wherein the formula variables are as defined herein, and pharmaceutically acceptable salts, solvates, active metabolites or prodrugs thereof.