Bahman B Anvari

US Patent:

8337809, Dec 25, 2012

Filed:

Sep 11, 2007

Appl. No.:

12/440715

Inventors:

Jie Yu - Houston TX, US
Michael Sha-nang Wong - Houston TX, US
Bahman Anvari - Tustin CA, US
Mohammad Abbas Yaseen - Somerville MA, US

Assignee:

William Marsh Rice University - Houston TX

International Classification:

A61K 51/00
A61K 51/12

US Classification:

424 129

Abstract:

Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.

US Patent:

20050234529, Oct 20, 2005

Filed:

Mar 17, 2005

Appl. No.:

11/082574

Inventors:

John Oghalai - Pearland TX, US
Bahman Anvari - Houston TX, US

Assignee:

Baylor College of Medicine - Houston TX
William Marsh Rice University - Houston TX

International Classification:

A61N005/067

US Classification:

607089000

Abstract:

A method and apparatus are disclosed for improving hearing by irradiating the cochlea with a laser beam. In one embodiment, an apparatus for improving hearing comprises a laser source that emits at least one laser beam to irradiate at least a portion of a basilar membrane. The laser source emits the at least one laser beam under suitable conditions to change a frequency response of the basilar membrane. In an embodiment, the laser source irradiates the cochlea at a defined pulse duration to change the physical properties of the cochlea. The irradiated portion of the cochlea may be the basilar membrane.

US Patent:

20110311455, Dec 22, 2011

Filed:

Jun 8, 2011

Appl. No.:

13/156218

Inventors:

Bahman Anvari - Tustin CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 49/00
A61K 31/403
A61K 31/409
A61K 31/197
B01J 19/12
A61K 49/22
A61K 49/04
A61K 49/18
A61K 9/14
A61K 9/00
A61K 31/221

US Classification:

424 93, 424400, 514411, 514410, 514561, 514551, 424 91, 424 95, 424 94, 427 21, 20415715

Abstract:

A nano-capsule construct for imaging and therapeutic uses and method for production are provided. One nano-probe embodiment based on genome-depleted plant brome mosaic virus (BMV) whose interior is doped with indocyanine green (ICG), an FDA-approved near infrared fluorescent dye, is used to illustrate the invention. The material encapsulated in viral shell components may be coated with functionalized coatings such as branched, dendritic polymer coatings to improve longevity and distribution in the body as well as antibody conjugation for increased target specificity. The constructs can also be coated with ferromagnetic iron oxide nanoparticles, enabling the ICG-containing capsules to be used as nano-probes with the capability of being detected in both optical and magnetic resonance imaging. The capsules may be produced by purifying a plant or animal viruses and disassembling the viruses to provide virus shell components. The virus shell components are reassembled in the presence of a material for encapsulation thereby encapsulating said material within the core of the construct in one embodiment.

US Patent:

59794542, Nov 9, 1999

Filed:

Jun 6, 1997

Appl. No.:

8/870467

Inventors:

Bahman Anvari - Irvine CA
Samuel B. Tanenbaum - Irvine CA
Thomas E. Milner - Irvine CA
J. Stuart Nelson - Laguna Niguel CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61N 506

US Classification:

128898

Abstract:

Successful laser treatment of hemangiomas requires selective photocoagulation of subsurface targeted blood vessels without thermal damage to the overlying epidermis. An apparatus for in vivo exposure of laser radiation from a continuous Nd:YAG laser at 1064 nm delivers repetitive cryogen spurts, each having a duration of the order of milliseconds during continuous laser irradiation. Control of the cryogen spray cooling is achieved through monitoring of the radiometric surface temperature of the tissue site and either controlling the repetition rate of the cryogen spurts according to temperature or according to a threshold temperature of the irradiated surface and/or repetition rate of the cryogen spurts according to power density and the duration of continuous irradiation.

US Patent:

5997530, Dec 7, 1999

Filed:

Apr 13, 1998

Appl. No.:

9/059537

Inventors:

J. Stuart Nelson - Laguna Niguel CA
Bahman Anvari - Houston TX
B. Samuel Tanenbaum - Irvine CA
Thomas E. Milner - Austin TX

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 1736

US Classification:

606 9

Abstract:

Cryogen spray cooling of skin surface with millisecond cryogen spurts is an effective method for establishing a controlled temperature distribution in tissue and protecting the epidermis from nonspecific thermal injury during laser mediated dermatological procedures. Control of humidity level, spraying distance and cryogen boiling point is material to the resulting surface temperature. Decreasing the ambient humidity level results in less ice formation on the skin surface without altering the surface temperature during the cryogen spurt. For a particular delivery nozzle, increasing the spraying distance to 85 millimeters lowers the surface temperature. The methodology comprises establishing a controlled humidity level in the theater of operation of the irradiation site of the biological tissues before and/or during the cryogenic spray cooling of the biological tissue. At cold temperatures calibration was achieved by mounting a thermistor on a thermoelectric cooler. The thermal electric cooler was cooled from from 20. degree. C.

US Patent:

62481037, Jun 19, 2001

Filed:

May 28, 1999

Appl. No.:

9/322311

Inventors:

Sam Tannenbaum - Claremont CA
Stuart Nelson - Laguna Niguel CA
Thomas Milner - Austin TX
Bahman Anvari - Houston TX

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 1818

US Classification:

606 9

Abstract:

A method for performing laser treatment of biological tissues is performed by cooling a selected portion of the biological tissue for a predetermined first time period to establish a predetermined nonequilibrium dynamic temperature gradient through the tissue so that substantially only the selected portion of the biological tissue is cooled by a predetermined minimum temperature drop. The temperature gradient is established by providing a spurt of a predetermined amount of cryogenic liquid in direct contact with the biological tissue. A superficial and deeper part of the selected portion of the biological tissue is immediately irradiated for a time period which is approximately equal to or in excess of one millisecond. The irradiation is effective to thermally treat the deeper part of the biological tissue while leaving the superficial part of the biological tissue substantially undamaged. Heat is quickly dissipated from the superficial part of the biological tissue by means of supplying the latent heat of vaporization to the cryogenic liquid.

US Patent:

20160250337, Sep 1, 2016

Filed:

Apr 16, 2013

Appl. No.:

13/864103

Inventors:

Bahman Anvari - Tustin CA, US

International Classification:

A61K 47/46
A61K 41/00
A61N 5/06

Abstract:

Certain embodiments of the present invention provide methods, of treating a skin abnormality in a mammalian subject, that involve introducing, into a vasculature of the subject, red blood cells (RBCs) that comprise a photosensitive compound; and then permitting to pass a time-period sufficient for some of the RBCs to enter a region of the subject that comprises the skin abnormality; and then exposing RBCs in the region to an amount of radiation energy sufficient to result in the photosensitive compound mediating a hyperthermic therapy, a thermal therapy, an oxygen singlet therapy, a radical molecule therapy, or a combination thereof on the skin abnormality. In some embodiments, the photosensitive compound comprises a dye and is substantially encapsulated within the RBCs. In some embodiments, the radiation energy consists essentially of radiation wavelengths absorbed substantially more efficiently by the photosensitive compound than by an epidermal tissue of the subject.