Barbara Jane Potts

US Patent:

7166634, Jan 23, 2007

Filed:

Jan 21, 2005

Appl. No.:

11/040923

Inventors:

Scott S. Mitchell - San Carlos CA, US
Kin S. Lam - San Diego CA, US
Jennifer Grodberg - Carlsbad CA, US
Barbara C. Potts - Escondido CA, US
Ginger Tsueng - San Diego CA, US
Donald J. White - San Deigo CA, US
Katherine Anne Reed - San Diego CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

A01N 43/38
A01N 43/36
C07D 209/10

US Classification:

514414, 548453, 548455

Abstract:

Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

US Patent:

7250438, Jul 31, 2007

Filed:

Jun 6, 2005

Appl. No.:

11/146613

Inventors:

Rama Rao Manam - San Diego CA, US
Barbara C. Potts - Escondido CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/407
C07D 491/107

US Classification:

514409, 548410

Abstract:

Disclosed herein are novel spiro beta-lactone/gamma lactams for use in treating bacterial infections and cancer. The compounds are characterized by a terminal electron-withdrawing group such as a nitro group. Screening data shows antimicrobial activity against various bacterial cell lines, particularly gram-positive bacteria, and anti-cancer activity.

US Patent:

7276530, Oct 2, 2007

Filed:

Apr 29, 2005

Appl. No.:

11/118260

Inventors:

Barbara Christine Potts - Escondido CA, US
Venkat Macherla - San Diego CA, US
Scott Sherman Mitchell - San Carlos CA, US
Ram Rao Manam - San Diego CA, US
Katherine Reed - San Diego CA, US
Kin Sing Lam - San Diego CA, US
Saskia Neuteboom - La Jolla CA, US
Ta-Hsiang Chao - San Diego CA, US
Benjamin Nicholson - San Diego CA, US
Cheryl Billstrom - San Diego CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/407
C07D 491/044

US Classification:

514421, 548453

Abstract:

Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

US Patent:

7375129, May 20, 2008

Filed:

Nov 20, 2006

Appl. No.:

11/602869

Inventors:

Scott S. Mitchell - San Carlos CA, US
Kin S. Lam - San Diego CA, US
Jennifer Grodberg - Carlsbad CA, US
Barbara C. Potts - Escondido CA, US
Ginger Tsueng - San Diego CA, US
Donald J. White - San Deigo CA, US
Katherine Anne Reed - San Diego CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/4025
A61K 31/404
C07D 209/10

US Classification:

514414, 548453, 548455, 514422

Abstract:

Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

US Patent:

7544814, Jun 9, 2009

Filed:

Oct 1, 2007

Appl. No.:

11/865704

Inventors:

Barbara Christine Potts - Escondido CA, US
Venkat Macherla - San Diego CA, US
Scott Sherman Mitchell - San Carlos CA, US
Ram Rao Manam - San Diego CA, US
Katherine A. McArthur - San Diego CA, US
Kin Sing Lam - San Diego CA, US
Saskia Neuteboom - La Jolla CA, US
Ta-Hsiang Chao - San Diego CA, US
Benjamin Nicholson - Merion Station PA, US
Cheryl L. Billstrom - San Diego CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/407
C07D 491/044

US Classification:

548453, 514421

Abstract:

Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

US Patent:

7579371, Aug 25, 2009

Filed:

Jun 15, 2006

Appl. No.:

11/453374

Inventors:

Michael Palladino - Olivenhain CA, US
Barbara Christine Potts - Escondido CA, US
Venkata Rami Reddy Macherla - San Diego CA, US
Saskia Theodora Cornelia Neuteboom - La Jolla CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/407
A61K 31/343

US Classification:

514421, 514469

Abstract:

Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.

US Patent:

7824698, Nov 2, 2010

Filed:

Feb 4, 2008

Appl. No.:

12/025679

Inventors:

Barbara Potts - Escondido CA, US
Ramsharan Singh - San Diego CA, US
Bao Viet Mai - San Diego CA, US
Natasha Reddinger - San Diego CA, US
Cheryl (Billstrom) Sifferlen - San Diego CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 9/00
A61K 31/4965
A61K 31/497
A01N 43/38
C07D 487/02

US Classification:

424400, 514421, 51425506, 51425411, 548453

Abstract:

Lyophilized formulations comprising Salinosporamide A or analogs thereof are provided. In some aspects, lyophilized formulations comprising Salinosporamide A or analogs thereof and bulking agents are provided. Also provided are methods of lyophilizing Salinosporamide A or analogs thereof. In some aspects, a solvent or co-solvent system is utilized. Also provided are methods of administering Salinosporamide A or analogs thereof to patients.

US Patent:

7842814, Nov 30, 2010

Filed:

Apr 6, 2007

Appl. No.:

11/697689

Inventors:

Taotao Ling - La Jolla CA, US
Venkata Rami Reddy Macherla - San Diego CA, US
Barbara Christine Potts - Escondido CA, US
Rama Rao Manam - San Diego CA, US
Katherine A. McArthur - La Mesa CA, US

Assignee:

Nereus Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07D 413/02
C07D 265/04
C07D 498/02
C07D 487/02
C07D 207/08

US Classification:

548217, 548215, 548218, 548453, 548543

Abstract:

The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).