Anthony Treston - Rockville MD, US Jamshed H. Shah - Columbia MD, US Robert J. D'Amato - Lexington MA, US Kimberly A. Hunsucker - Alpharetta GA, US John Rougas - Westchester PA, US Barry P. Conner - Laurel MD, US Glenn M. Swartz - Mt. Airy MD, US
Assignee:
The Children's Medical Center Corporation - Boston MA
International Classification:
C07D 401/06
US Classification:
546201
Abstract:
The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(−)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.
Anthony Treston - Rockville MD, US Jamshed H. Shah - Columbia MD, US Robert J. D'Amato - Lexington MA, US Kimberly A. Hunsucker - Germantown MD, US John Rougas - Westchester PA, US Barry P. Conner - Laurel MD, US Glenn M. Swartz - Mt. Airy MD, US
Assignee:
The Children's Medical Center Corporation - Boston MA
International Classification:
C07D 401/06
US Classification:
546201
Abstract:
The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(−)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.
Synthesis And Anti-Tumor Activity Of Nitrogen Substituted Thalidomide Analogs
Jamshed Shah - Brookeville MD, US Barry Conner - Laurel MD, US Glenn Swartz - Mt. Airy MD, US Kimberly Hunsucker - Alpharetta GA, US John Rougas - Germantown MD, US Robert D'Amato - Lexington MA, US Victor Pribluda - Silver Spring MD, US Anthony Treston - Rockville MD, US
International Classification:
A61K031/454
US Classification:
514/323000
Abstract:
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.
Synthesis And Anti-Tumor Activity Of Nitrogen Substituted Thalidomide Analogs
Anthony Treston - Rockville MD, US Jamshed Shah - Brookeville MD, US Robert D'Amato - Lexington MA, US Barry Conner - Laurel MD, US Kimberly Hunsucker - Alpharetta GA, US John Rougas - Germantown MD, US Glenn Swartz - Mt. Airy MD, US Victor Pribluda - Silver Spring MD, US
International Classification:
A61K 31/454
US Classification:
514323000
Abstract:
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.
Methods For Treating Macular Degeneration Using 4-(Amino)-2-(2,6-Dioxo(3-Piperidyle))-Isoindoline-1,3-Dione
Anthony Treston - Rockville MD, US Jamshed H. Shah - Columbia MD, US Robert J. D'Amato - Lexington MA, US Kimberly A. Hunsucker - Germantown MD, US John Rougas - Westchester PA, US Barry P. Conner - Laurel MD, US Glenn M. Swartz - Mt. Airy MD, US
International Classification:
A61K 31/454 A61P 27/02
US Classification:
514323
Abstract:
Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, alone or in combination with a second active agent and/or surgery.
Special effects and production specialist Barry Conner says that by the final day, the personal assistants hired to retrieve the balls had mostly left, and they were relying on spectators who had started gathering to watch the filming to collect them instead.