Barry H Ginsberg

US Patent:

7404796, Jul 29, 2008

Filed:

Mar 1, 2004

Appl. No.:

10/788475

Inventors:

Barry H. Ginsberg - Wyckoff NJ, US

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

A61B 5/00
A61B 5/05
A61M 31/00

US Classification:

600365, 600300, 604 65, 604 66

Abstract:

An apparatus and method are provided for determining a patient's carbohydrate to insulin ratio (CIR) and insulin sensitivity factor (ISF), and using these values, along with values for current blood glucose level and deviation from target blood glucose level, for determining insulin dose in view of carbohydrate intake during a particular time period. The apparatus and method employ algorithms that can be implemented in any of a personal computer, personal data assistant, hand held computing device, blood glucose monitor, infusion pump, medication delivery pen, meter, calculator, among other therapeutic, diagnostic or informational devices used for managing a patient's blood glucose levels.

US Patent:

7570980, Aug 4, 2009

Filed:

Sep 10, 2003

Appl. No.:

10/658209

Inventors:

Barry H. Ginsberg - Wyckoff NJ, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61B 5/00

US Classification:

600347, 600365

Abstract:

A method of presenting glucose data to a person with diabetes from a blood glucose meter is provided in which an effective meal average (EMA) value is presented, followed by two or more of the individual values that make up the EMA, to provide improved feedback data for clinical decisions by patients who need to alter their dose of insulin. The EMA can also comprise a measure of the variability of its constituent values. The EMA encompasses those values that occur at specified times such as 1 hour before and 1 hour after a specified meal time. The EMA is calculated over a limited number of days previous to the calculation (e. g. , 3 days) and has a minimum number of values that must be obtained within the time and date ranges. An algorithm allows for exclusion of any given reading from the average (e. g. , post-prandial or control solution readings).

US Patent:

7722595, May 25, 2010

Filed:

May 6, 2003

Appl. No.:

10/429973

Inventors:

Ronald J. Pettis - Cary NC, US
Noel Harvey - Efland NC, US
Barry Ginsberg - Wyckoff NJ, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61M 31/00

US Classification:

604500, 604173

Abstract:

The invention pertains to methods and devices for controlling the pharmacokinetics of administered substances, particularly therapeutic substances by combining advantages of delivery to two or more compartments within the skin. The invention provides methods and devices for delivering substances to subcutaneous and intradermal compartments of the skin to achieve a hybrid pharmacokinetic profile that has a portion similar to that achieved by intradermal delivery, e. g. , rapid and high peak onset levels of the substance, and a portion similar to that achieved by subcutaneous delivery, e. g. , longer circulating levels of the substance.

US Patent:

8246540, Aug 21, 2012

Filed:

Jul 1, 2008

Appl. No.:

12/216231

Inventors:

Barry H. Ginsberg - Wyckoff NJ, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61M 31/00
A61B 5/05

US Classification:

600365, 604 66

Abstract:

An apparatus and method are provided for determining a patient's carbohydrate to insulin ratio (CIR) and insulin sensitivity factor (ISF), and using these values, along with values for current blood glucose level and deviation from target blood glucose level, for determining insulin dose in view of carbohydrate intake during a particular time period. The apparatus and method employ algorithms that can be implemented in any of a personal computer, personal data assistant, hand held computing device, blood glucose monitor, infusion pump, medication delivery pen, meter, calculator, among other therapeutic, diagnostic or informational devices used for managing a patient's blood glucose levels.

US Patent:

8285487, Oct 9, 2012

Filed:

Mar 23, 2007

Appl. No.:

12/293120

Inventors:

Chris Bergstrom - Ramsey NJ, US
Jay Butterbrodt - Andover MA, US
Alan W. Fiedler - Wayne NJ, US
Barry Ginsberg - Wyckoff NJ, US
Tim H. Gordon - Rivervale NJ, US
Paul Upham - Jersey City NJ, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

G01N 33/48
G01N 33/00

US Classification:

702 19, 436 95

Abstract:

Methods, devices and a system for disease management are provided that employ diagnostic testing devices (e. g. , blood glucose meters) and medication delivery devices (e. g. , insulin delivery devices) for providing data to a repository in real-time and automatically. Repository data can be analyzed to determine such information as actual test strip use, patient health parameters to outside prescribed ranges, testing and medication delivery compliance, patient profiles or stakeholders to receive promotional items or incentives, and so on. Connected meters and medication delivery devices and repository data analysis are also employed to associate a diagnostic test to a mealtime based on timing of a therapeutic intervention performed by an individual.

US Patent:

20050055010, Mar 10, 2005

Filed:

May 6, 2004

Appl. No.:

10/841992

Inventors:

Ronald Pettis - Durham NC, US
Noel Harvey - Efland NC, US
Barry Ginsberg - Wyckoff NJ, US

International Classification:

A61K038/28
A61M031/00

US Classification:

604500000, 514003000

Abstract:

The present invention relates to methods for administration of insulin into the intradermal compartment of subject's skin, preferably to the dermal vasculature of the intradermal compartment. The methods of the present invention enhance the pharmacokinetic and pharmacodynamic parameters of insulin delivery and effectively result in a superior clinical efficacy in the treatment and/or prevention of diabetes mellitus. The methods of the instant invention provide an improved glycemic control of both non-fasting (i.e., post-prandial) and fasting blood glucose levels and thus have an enhanced therapeutic efficacy in treatment, prevention and/or management of diabetes relative to traditional methods of insulin delivery, including subcutaneous insulin delivery.

US Patent:

20090240129, Sep 24, 2009

Filed:

Jun 3, 2009

Appl. No.:

12/457185

Inventors:

Barry H. Ginsberg - Wyckoff NJ, US

International Classification:

A61B 5/145

US Classification:

600365

Abstract:

A method of presenting glucose data to a person with diabetes from a blood glucose meter is provided in which an effective meal average (EMA) value is presented, followed by two or more of the individual values that make up the EMA, to provide improved feedback data for clinical decisions by patients who need to alter their dose of insulin. The EMA can also comprise a measure of the variability of its constituent values. The EMA encompasses those values that occur at specified times such as 1 hour before and 1 hour after a specified meal time. The EMA is calculated over a limited number of days previous to the calculation (e.g., 3 days) and has a minimum number of values that must be obtained within the time and date ranges. An algorithm allows for exclusion of any given reading from the average (e.g., post-prandial or control solution readings). Patients can use 1 to 8 EMA on any given date range (e.g., preferably 4, that is, breakfast, lunch, supper and bedtime snack).

US Patent:

20100262120, Oct 14, 2010

Filed:

Apr 7, 2010

Appl. No.:

12/755540

Inventors:

Ronald J. Pettis - Cary NC, US
Noel Harvey - Efland NC, US
Barry Ginsberg - Wyckoff NJ, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

A61M 5/32

US Classification:

604506

Abstract:

Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling.