Barry I Schweitzer

age ~64

from Bethel, VT

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Also known as:

Barry L Schweitzer
Barry T Schweitzer
Barry I Schweitz
Schweitzer I Barry
Schweitzer Barri

Connected to:

Barry Schweitzer Phones & Addresses

Bethel, VT
Quechee, VT
459 Maple Ave, Cheshire, CT 06410 • 2032711521
100 Stirling Ave, Winter Park, FL 32789 • 4076455084
157 Peck Hill Rd, Woodbridge, CT 06525 • 2033931662 • 2033931706
Bethany, CT
Branford, CT
Orange, CT
157 Peck Hill Rd, Woodbridge, CT 06525 • 2035368850

Work

Position:

Sales Occupations

Education

Degree:

Bachelor's degree or higher

Emails

t***[email protected]

Us Patents

Protein Expression Profiling
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US Patent:

6921642, Jul 26, 2005
Filed:

Jan 13, 2003
Appl. No.:

10/341287
Inventors:

Stephen Kingsmore - Guilford CT, US
Girish Nallur - Guilford CT, US
Barry Schweitzer - Woodbridge CT, US
Assignee:

QLAGEN GmbH
International Classification:

C12Q001/68
C12P019/34
C12M001/00
C07H021/04
C07K001/00
US Classification:

435 6, 435 911, 435 912, 4352831, 536 231, 536 243, 536 2432, 536 2433, 530350
Abstract:

Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a primer with an analyte and subsequently using the primer to mediate rolling circle replication of a circular DNA molecule. Amplification of the DNA circle is dependent on the presence of the primer. Thus, the disclosed method produces an amplified signal, via rolling circle amplification, from any analyte of interest. The amplified DNA remains associated with the analyte, via the primer, and so allows spatial detection of the analyte. The disclosed method can be used to detect and analyze proteins and peptides. Multiple proteins can be analyzed using microarrays to which the various proteins are immobilized. A rolling circle replication primer is then associated with the various proteins using a conjugate of the primer and a molecule that specifically binds the proteins to be detectable. Rolling circle replication from the primers results in production of a large amount of DNA at the sites in the array where the proteins are immobilized.

Methods For Conducting Assays For Enzyme Activity On Protein Microarrays
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US Patent:

7635572, Dec 22, 2009
Filed:

Jun 9, 2004
Appl. No.:

10/865431
Inventors:

Fang X. Zhou - New Haven CT, US
Barry Schweitzer - Cheshire CT, US
Assignee:

Life Technologies Corporation - Carlsbad CA
International Classification:

C12Q 1/50
US Classification:

435 17
Abstract:

The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.

Immune Modulatory Activity Of Human Ribonucleases
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US Patent:

20040009503, Jan 15, 2004
Filed:

Mar 26, 2003
Appl. No.:

10/396317
Inventors:

Qin Fu - Baltimore MD, US
Velizar Tchernev - Branford CT, US
Ebenezer Satyaraj - Hamden CT, US
Dhavalkumar Patel - Durham NC, US
Stephen Kingsmore - Guilford CT, US
Barry Schweitzer - Woodbridge CT, US
Assignee:

Molecular Staging, Inc. - New Haven CT
International Classification:

C12Q001/68
US Classification:

435/006000
Abstract:

Human extracellular ribonucleases (RNases) are widely distributed in various organs and body fluids and together with other members of the mammalian RNase A superfamily. In addition to their RNase activity, several RNases have been shown to have special biological actions, i.e., antitumor, antiviral and angiogenic properties. However, the molecular mechanisms of such activities are unclear. Using protein microarrays amplified rolling circle amplification (RCA), we investigated the effects of EDN (Rnase 2), ECP (Rnase 3) and RNase 1 on leukocytes cytokine production. We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with different combinations of RNases and RNase inhibitors. Members of human ribonuclease family (such as Rnase 1, hEDN (Rnase 2) and Rnase 3) induced expression of certain sets of cytokines in human leukocytes, including ENA-78, EOT2, BLC, GDNF, 1309, IFN-, IFN-, IL-10, IL-12P40, IL-12p70, IL-13, IL-16, IL-18, IL-1, IL-1ra, IL-2Sra, IL-3, IL-6, IL-6sR, IL-7, IL-8, IP-10, MCP-1, MCP-2, MCP-3, MCSF, MIG, MDC, MIP-1, MIP-1, MPIF-1, NAP-2, RANTES, sCD23, OSM, TARC, TNF-, TNF-R1 and uPAR. Thus members of the Rnase superfamily are therapeutic targets for treatment of inflammatory diseases and clinical conditions. Inhibition or augmentation of Rnase expression is used to modulate the immune system and is beneficial for host defense against various diseases and is exploited as an adjuvant. The expression of Rnases is a diagnostic marker for inflammation related conditions and is used to determine various disease stages. In addition, expression of cytokines, chemokines, growth factors is used to monitor efficacy of Rnase-base therapies.

Use Of Cytokines Secreted By Dendritic Cells
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US Patent:

20040072237, Apr 15, 2004
Filed:

Nov 12, 2002
Appl. No.:

10/291797
Inventors:

Barry Schweitzer - Woodbridge CT, US
International Classification:

G01N033/53
G01N033/567
US Classification:

435/007100, 435/007200
Abstract:

A prerequisite of proteomics is the ability to quantify many selected proteins simultaneously. Fluorescent sandwich immunoassays on microarrays hold appeal for such studies, since equipment and antibodies are readily available, and assays are simple, scalable and reproducible. To attain adequate sensitivity and specificity, however, a general method of immunoassay amplification is required. Coupling of isothermal rolling circle amplification (RCA) to universal antibodies can be used for this purpose: RCA on a synthetic DNA circle is initiated by a complementary oligonucleotide attached to an anti-biotin antibody; single-stranded RCA product remains attached to the antibody, and is detected by hybridization of complementary, fluorescent oligonucleotides. 51 cytokines were measured simultaneously on microarrays with signal amplification by RCA with high specificity, femtomolar sensitivity and 4 log quantitative range. This cytokine microarray was used to measure secretion from human Dendritic cells (DCs) induced by lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-(). Rapid secretion of inflammatory cytokines such as MIP-1, IL-8, and IP-10 was induced by LPS. Eotaxin-2 and I-309 were found to be induced by LPS, and MDC, TARC, sIL-6R, and sTNF-RI were found to be induced by TNF-. Since microarrays can accommodate 1000 sandwich immunoassays of this type, a relatively small number of RCA microarrays appears to offer a tractable approach for proteomic surveys.

Methods For Conducting Assays For Enzyme Activity On Protein Microarrays
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US Patent:

20040248323, Dec 9, 2004
Filed:

Jun 9, 2003
Appl. No.:

10/458720
Inventors:

Fang Zhou - New Haven CT, US
Barry Schweitzer - Cheshire CT, US
Assignee:

Protometrix, Inc.
International Classification:

C12Q001/37
G01N033/543
US Classification:

436/518000, 435/023000
Abstract:

The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.

Method For Providing Protein Microarrays
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US Patent:

20060099704, May 11, 2006
Filed:

Jul 14, 2005
Appl. No.:

11/183295
Inventors:

Paul Predki - Carlsbad CA, US
Barry Schweitzer - Cheshire CT, US
International Classification:

G06Q 99/00
C12M 1/34
US Classification:

435287200, 705001000
Abstract:

The present application relates to methods for providing a protein microarray product and related products and services to a customer, methods, kits, and systems for labeling a probe for a protein microarray, and methods for determining protein concentrations using a protein microarray. The methods for providing a protein micorarray can include, in certain aspects, a computer function for performing some of the steps of the methods. Methods and kits for labeling a probe can include a control array that includes a molecule that binds to a label of a probe.

Collections Of Matched Biological Reagents And Methods For Identifying Matched Reagents
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US Patent:

20060100788, May 11, 2006
Filed:

Apr 22, 2005
Appl. No.:

11/112933
Inventors:

John Carrino - San Diego CA, US
Feng Liang - San Diego CA, US
Siamak Baharloo - Carlsbad CA, US
Barry Schweitzer - Cheshire CT, US
Assignee:

Invitrogen Corporation - Carlsbad CA
International Classification:

G06Q 10/00
G06F 19/00
US Classification:

702019000, 702020000, 705002000
Abstract:

Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods for selecting an isolated biomolecule or biological research reagent from a collection of biological reagents.

Compositions, Kits And Assays Containing Reagents Directed To Cortactin And An Arg/Abl Protein Kinase
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US Patent:

20060141529, Jun 29, 2006
Filed:

Jul 27, 2005
Appl. No.:

11/191644
Inventors:

Anthony Koleske - Cheshire CT, US
Scott Boyle - Hamden CT, US
Greg Michaud - Clinton CT, US
Barry Schweitzer - Cheshire CT, US
Paul Predki - Hamden CT, US
International Classification:

G01N 33/53
US Classification:

435007100
Abstract:

It has been determined Cortactin interacts with an ARG/ABL protein kinase. Thus, provided herein are compositions, kits and assays containing reagents directed to Cortactin and an ARG/ABL protein kinase.