Bart W Nieuwenhuijsen

US Patent:

8337820, Dec 25, 2012

Filed:

May 17, 2012

Appl. No.:

13/506801

Inventors:

Bart Nieuwenhuijsen - Penn Valley PA, US

International Classification:

A61K 8/18
A61Q 17/04

US Classification:

424 60, 424 59

Abstract:

A topical skin care dihydroxyacetone-free final gel formulation to protect skin from ultraviolet rays comprising dispersed: titanium dioxide; 5-hydroxy-tryptophan; histidine; and N-acetyl-tyrosine.

US Patent:

20080182296, Jul 31, 2008

Filed:

Jan 31, 2008

Appl. No.:

12/023756

Inventors:

Pranab K. Chanda - West Windsor NJ, US
Bart W. Nieuwenhuijsen - Philadelphia PA, US

International Classification:

C12P 21/04
C12P 21/00
C07K 16/00
C07H 21/04

US Classification:

435 691, 435 912, 536 232, 530350

Abstract:

The present invention provides methods of PCR-directed gene synthesis that may be used for all genes, including those with a high G+C content and/or a long sequence. The invention relates to methods of gene synthesis using overlapping oligonucleotides and polymerase chain reaction (PCR), wherein several PCR parameters, e.g., the concentration of overlapping oligonucleotides, the type of DNA polymerase used, and the number of PCR amplification cycles, are optimized. Additionally, the invention relates to oligonucleotide design that allows for increased protein expression of synthesized genes.

US Patent:

20090202445, Aug 13, 2009

Filed:

Feb 12, 2009

Appl. No.:

12/370577

Inventors:

Bart Nieuwenhuijsen - Philadelphia PA, US

International Classification:

A61K 9/00
A61K 31/4415

US Classification:

424 43, 424 941

Abstract:

The object of the present invention is to provide an all-natural dietary supplement formulation that may be beneficial to the management of behavioral and neurological symptoms associated with autism spectrum disorders; symptoms that may not be effectively improved by conventional drug treatment and behavioral therapy alone.

US Patent:

20090202460, Aug 13, 2009

Filed:

Feb 13, 2009

Appl. No.:

12/371327

Inventors:

Bart Nieuwenhuijsen - Philadelphia PA, US

International Classification:

A61K 8/49
A61Q 17/04

US Classification:

424 60

Abstract:

The object of the invention is to provide a topical preparation for (acne) rosacea and other sensitive skin types that protects the face from harmful UV rays without the use of chemical sunscreen ingredients. It has long been found that chemical sunscreen ingredients (most popular are oxybenzone and avobenzone) can cause an increase of rosacea symptoms (flushing, erythema, papules) (Nedorost (2003) and Landers et al., 2003). Furthermore, typical waterproof sunscreen preparations also contain various forms of silicones that are used to increase the hydrophobicity of the sunscreen. These waterproof sunscreen preparations impair the release of heat from the skin. The combination of this “trapped heat” and a sensitivity to chemical sunscreen ingredients, is harmful to rosacea skin. Therefore, a sunscreen preparation that is water-soluble and uses alternative UV absorbing and UV scattering ingredients would be very useful in protecting rosacea skin from harmful UV rays.