Baruch S Blumberg

US Patent:

6465487, Oct 15, 2002

Filed:

Dec 10, 1998

Appl. No.:

09/209033

Inventors:

Timothy M. Block - Doylestown PA
Raymond A. Dwek - North Hinskey, GB
Baruch S. Blumberg - Philadelphia PA
Anand Mehta - Landenberg PA
Frances Platt - Long Hanborough, GB
Terry D. Butters - Garsington, GB
Nicole Zitzmann - Odendorf, DE

Assignee:

Synergy Pharmaceuticals, Inc. - Somerset NJ
Thomas Jefferson University - Philadelphia PA
The Chancellor, Masters and Scholars of the University of Oxford - Oxford

International Classification:

A61K 31445

US Classification:

514315, 514317, 514326, 514327, 514328

Abstract:

Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.

US Patent:

46735755, Jun 16, 1987

Filed:

Apr 26, 1985

Appl. No.:

6/727452

Inventors:

Pinayur S. Venkateswaran - Chester PA
Irving Millman - Willow Grove PA
Baruch S. Blumberg - Philadelphia PA

Assignee:

Fox Chase Cancer Center - Philadelphia PA

International Classification:

A61K 3578

US Classification:

4241951

Abstract:

A pharmaceutical preparation comprising the methanol extractable components of Phyllanthus niruri L. is administered to patients suffering from hepatitis B virus infection in an amount effective for inhibiting the growth of said virus.

US Patent:

41894642, Feb 19, 1980

Filed:

May 5, 1978

Appl. No.:

5/903238

Inventors:

Baruch S. Blumberg - Philadelphia PA
Irving Millman - Willow Grove PA

Assignee:

Institute for Cancer Research - Philadelphia PA

International Classification:

G01N 3316
A61K 4300
G21H 502

US Classification:

424 1

Abstract:

A test reagent reagent for HB. sub. s A. sub. g is prepared by applying to a suitable substrate, such as a polystyrene bead, a first coat of purified HB. sub. s A. sub. g to an extent which will permit complete coverage by anti-HB. sub. s. After washing HB. sub. s A. sub. g coated substrate, serum containing anti-HB. sub. s, or an IgG fraction of serum containing anti-HB. sub. s, is applied as a second coat as a second coat in an amount which substantially completely occupies the reacting sites of the HB. sub. s A. sub. g on the outside of the substrate and leaves an excess of antibody reacting groups in a free state, and any unattached material is washed off. A test sample which is to be tested for HB. sub. s A. sub. g is then contacted with the reagent thus produced, permitting attachment of HB. sub. s A. sub. g if present, and washing is done.

US Patent:

49370740, Jun 26, 1990

Filed:

Mar 29, 1988

Appl. No.:

7/174695

Inventors:

Pinayur S. Venkateswaran - Chester PA
Irving Millman - Willow Grove PA
Baruch S. Blumberg - Philadelphia PA

Assignee:

Fox Chase Cancer Center - Philadelphia PA

International Classification:

A61K 3578

US Classification:

4241951

Abstract:

Method of treating retrovirus infection by administering extract of Phyllanthus niruri.

US Patent:

60373512, Mar 14, 2000

Filed:

Jul 11, 1996

Appl. No.:

8/676153

Inventors:

Timothy M. Block - Jenkintown PA
Baruch S. Blumberg - Philadelphia PA
Raymond A. Dwek - Oxford, GB

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A61K 31445

US Classification:

514315

Abstract:

A method is disclosed for the treatment of hepatitis B virus (HBV) infections which comprises administering to the infected host an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which the alkyl group contains from 3 to 6 carbon atoms.