Benjamin Edward Shepherd

US Patent:

20130164339, Jun 27, 2013

Filed:

Sep 12, 2012

Appl. No.:

13/612778

Inventors:

Keith Murphy - Palos Verdes Estates CA, US
Chirag Khatiwala - San Diego CA, US
Scott Dorfman - San Diego CA, US
Benjamin Shepherd - San Diego CA, US
Sharon Presnell - San Diego CA, US

Assignee:

ORGANOVO, INC. - San Diego CA

International Classification:

A61L 27/36
A01N 1/02
A61L 27/38

US Classification:

424400, 424 937, 424 933, 435 2, 427 224

Abstract:

Disclosed are engineered tissues and organs comprising one or more muscle cell-containing layers, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.

US Patent:

20130190210, Jul 25, 2013

Filed:

Sep 12, 2012

Appl. No.:

13/612768

Inventors:

Keith Murphy - Palos Verdes Estates CA, US
Chirag Khatiwala - San Diego CA, US
Scott Dorfman - San Diego CA, US
Benjamin Shepherd - San Diego CA, US
Sharon Presnell - San Diego CA, US
Justin Robbins - La Jolla CA, US

Assignee:

ORGANOVO, INC. - San Diego CA

International Classification:

G01N 33/50

US Classification:

506 14, 435325, 435401, 435402, 435 29, 506 26, 264309

Abstract:

Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

US Patent:

20130345794, Dec 26, 2013

Filed:

Mar 16, 2011

Appl. No.:

13/634863

Inventors:

Chirag Khatiwala - San Diego CA, US
Keith Murphy - Palos Verdes Estates CA, US
Benjamin Shepherd - San Diego CA, US

Assignee:

ORGANOVO, INC. - San Diego CA

International Classification:

A61F 2/06

US Classification:

623 135, 623 141

Abstract:

Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.

US Patent:

20210123906, Apr 29, 2021

Filed:

Sep 4, 2020

Appl. No.:

17/013165

Inventors:

- San Diego CA, US
Chirag KHATIWALA - San Diego CA, US
Scott DORFMAN - San Diego CA, US
Benjamin SHEPHERD - San Diego CA, US
Sharon PRESNELL - San Diego CA, US
Justin ROBBINS - La Jolla CA, US

International Classification:

G01N 33/50
A61L 27/34
A61L 27/38
A61L 27/50
C12N 5/071

Abstract:

Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

US Patent:

20200197152, Jun 25, 2020

Filed:

Aug 5, 2019

Appl. No.:

16/531605

Inventors:

- San Diego CA, US
Chirag KHATIWALA - San Diego CA, US
Scott DORFMAN - San Diego CA, US
Benjamin SHEPHERD - San Diego CA, US
Sharon PRESNELL - San Diego CA, US

International Classification:

A61F 2/02
A61L 27/38

Abstract:

Disclosed are engineered tissues and organs comprising one or more layers of muscle, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.

US Patent:

20200188082, Jun 18, 2020

Filed:

Aug 14, 2019

Appl. No.:

16/540934

Inventors:

- San Diego CA, US
Keith MURPHY - San Diego CA, US
Benjamin SHEPHERD - San Diego CA, US

International Classification:

A61F 2/06
C12N 5/071
A61L 27/50
A61L 27/38

Abstract:

Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.

US Patent:

20200116702, Apr 16, 2020

Filed:

Dec 12, 2019

Appl. No.:

16/712645

Inventors:

- San Diego CA, US
- Portland OR, US
Vivian A. GORGEN - San Diego CA, US
Benjamin R. SHEPHERD - San Diego CA, US
Sharon C. PRESNELL - San Diego CA, US
Rosalie SEARS - Portland OR, US
Ellen LANGER - Portland OR, US

International Classification:

G01N 33/50
C12N 5/077
B33Y 80/00
B33Y 10/00
C12N 5/09
C12N 5/071

Abstract:

Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.

US Patent:

20190062707, Feb 28, 2019

Filed:

Aug 10, 2018

Appl. No.:

16/100655

Inventors:

- San Diego CA, US
Benjamin R. SHEPHERD - San Diego CA, US

International Classification:

C12N 5/077
A61L 27/38
C12N 5/00

Abstract:

Disclosed are engineered, living, three-dimensional connective tissue constructs comprising connective tissue cells. In some embodiments, the connective tissue cells are derived from multi-potent cells such as mesenchymal stem/stromal cells. In some embodiments, the cells are cohered to one another. In some embodiments, the multi-potent cells have been exposed to one or more differentiation signals to provide a living, three-dimensional connective tissue construct. In some embodiments, the constructs are substantially free of pre-formed scaffold at the time of use. Also disclosed are implants for engraftment, arrays of connective tissue constructs for in vitro experimentation, as well as methods of making the same.