Bernhard Michael Lampert

US Patent:

20120058976, Mar 8, 2012

Filed:

Aug 31, 2011

Appl. No.:

13/223249

Inventors:

Roy W. Ware - Raleigh NC, US
Merrick R. Almond - Apex NC, US
Bernhard M. Lampert - Rougemont NC, US

Assignee:

Chimerix, Inc. - Durham NC

International Classification:

A61K 31/675
C07F 9/09

US Classification:

514 86, 544243, 558 90

Abstract:

The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

US Patent:

20130035313, Feb 7, 2013

Filed:

Feb 14, 2011

Appl. No.:

13/577602

Inventors:

Merrick Almond - Apex NC, US
Bernhard Lampert - Rougemont NC, US
Ernest Randall Lanier - Chapel Hill NC, US
Roy W. Ware - Raleigh NC, US

International Classification:

C07F 9/6561
A61P 31/12
A61K 31/675

US Classification:

514 81, 544244

Abstract:

The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein M is Na, Li, K, Ca, Mg, or NRRRR and R, R, Rand Rare each independently hydrogen or Calkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.

US Patent:

20140046085, Feb 13, 2014

Filed:

Oct 18, 2013

Appl. No.:

14/057391

Inventors:

Merrick R. Almond - Apex NC, US
Bernhard M. Lampert - Rougemont NC, US

Assignee:

CHIMERIX, INC. - Durham NC

International Classification:

C07F 9/40

US Classification:

558 45

Abstract:

The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

US Patent:

20150329575, Nov 19, 2015

Filed:

Jul 24, 2015

Appl. No.:

14/808388

Inventors:

- Durham NC, US
Merrick R. Almond - Apex NC, US
Bernhard M. Lampert - Rougemont NC, US

International Classification:

C07F 9/6512

Abstract:

The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

US Patent:

20150203519, Jul 23, 2015

Filed:

Mar 30, 2015

Appl. No.:

14/672816

Inventors:

- Durham NC, US
Bernhard Lampert - Rougemont NC, US
Ernest Randall Lanier - Chapel Hill NC, US
Roy W. Ware - Raleigh NC, US

International Classification:

C07F 9/6561

Abstract:

The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: