Bert W O'Malley from 6602 Brompton Rd, Houston, TX 77005, age 88, Phone: 8326236583

Bert W . O'malley

Work:

Position:

President

Education:

Studied at:

University of Pittsburgh • University of Pittsburgh School of Medicine

Academic degree:

Member of the United States National Academy of Sciences • Professor • Bachelor's Degree

Area of science:

Endocrinology

Specialty:

Director

Skills & Activities:

Award:

National Medal of Science laureate

Skill:

Scientific

Us Patents

Gene Switch Systems Employing Regulators With Decreased Dimerization
view source
US Patent:

7579326, Aug 25, 2009
Filed:

Mar 25, 2003
Appl. No.:

10/400053
Inventors:

Ronald V Abruzzese - The Woodlands TX, US
Vidya Mehta - Houston TX, US
Jeffrey L Nordstrom - College Station TX, US
Jason Fewell - The Woodlands TX, US
Bert O'Malley - Houston TX, US
Sophia Tsai - Houston TX, US
Assignee:

Genetronics, Inc. - San Diego CA
Baylor College of Medicine - Houston TX
International Classification:

A01N 43/04
A61K 31/70
A01N 63/00
A01N 65/00
C12N 15/00
C07H 19/00
C07H 21/00
C07H 21/04
US Classification:

514 44, 424 931, 4353201, 536 231, 536 234, 536 245, 536 241
Abstract:

Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.

Modified Steroid Hormones For Gene Therapy And Methods For Their Use
view source
US Patent:

20020147327, Oct 10, 2002
Filed:

Jul 25, 2001
Appl. No.:

09/916145
Inventors:

Bert O'Malley - Houston TX, US
Ming-Jer Tsai - Houston TX, US
Sophia Tsai - Houston TX, US
Harry Ledebur - Spring TX, US
Yaolin Wang - Iselin NJ, US
Joseph Kittle - Houston TX, US
International Classification:

C07H021/04
C12P021/02
C12N005/06
C07K014/72
US Classification:

536/023500, 530/350000, 435/069100, 435/320100, 435/325000
Abstract:

The present invention provides modified proteins of steroid hormone receptors. These mutated proteins are useful as gene medicines. In particular, these mutated proteins are useful for regulating expression of genes in gene therapy. In addition, the present invention provides plasmids encoding for the desired mutated steroid hormone receptor proteins, as well as cells transfected with those plasmids.

Mutated Steroid Hormone Receptors, Methods For Their Use And Molecular Switch For Gene Therapy
view source
US Patent:

20020182698, Dec 5, 2002
Filed:

Apr 16, 2002
Appl. No.:

10/124739
Inventors:

Bert O'Malley - Houston TX, US
Ming-Jer Tsai - Houston TX, US
Sophia Tsai - Houston TX, US
Harry Ledebur - Spring TX, US
Yaolin Wang - Iselin NJ, US
Joseph Kittle - Houston TX, US
Assignee:

Baylor College of Medicine
International Classification:

C12N009/22
C07H021/04
C12N005/06
C12P021/02
US Classification:

435/199000, 536/023200, 435/069100, 435/325000, 435/320100, 530/358000
Abstract:

The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch protein for regulating expression in gene therapy.

Mutated Steroid Hormone Receptors, Methods For Their Use And Molecular Switch For Gene Therapy
view source
US Patent:

20030109683, Jun 12, 2003
Filed:

Apr 16, 2002
Appl. No.:

10/124741
Inventors:

Bert O'Malley - Houston TX, US
Ming-Jer Tsai - Houston TX, US
Sophia Tsai - Houston TX, US
Harry Ledebur - Spring TX, US
Yaolin Wang - Iselin NJ, US
Joseph Kittle - Houston TX, US
International Classification:

C07K014/72
C07H021/04
C12P021/02
C12N005/06
US Classification:

530/395000, 536/023500, 435/069700, 435/320100, 435/325000
Abstract:

The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch protein for regulating expression in gene therapy.

Intratumorally Administered Lactoferrin In The Treatment Of Malignant Neoplasms And Other Hyperproliferative Diseases
view source
US Patent:

20040082504, Apr 29, 2004
Filed:

May 9, 2003
Appl. No.:

10/435319
Inventors:

Atul Varadhachary - Houston TX, US
Rick Barsky - Houston TX, US
Karel Petrak - Houston TX, US
Bert O'Malley - Houston TX, US
International Classification:

A61K038/40
US Classification:

514/006000
Abstract:

The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies.

Production Of Recombinant Lactoferrin And Lactoferrin Polypeptides Using Cdna Sequences In Various Organisms
view source
US Patent:

20050064546, Mar 24, 2005
Filed:

Jul 15, 2003
Appl. No.:

10/620256
Inventors:

Orla Conneely - Houston TX, US
Denis Headon - Galway, IE
Bert O'Malley - Houston TX, US
Gregory May - Houston TX, US
International Classification:

C07H021/04
C12N009/02
C12N009/32
C12N001/16
C12N001/18
C12N005/06
C12N015/74
US Classification:

435069100, 435189000, 435204000, 435254200, 435254300, 435348000, 435320100, 536023200
Abstract:

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.

Intratumorally Administered Lactoferrin In The Treatment Of Malignantneoplasms And Other Hyperproliferative Diseases
view source
US Patent:

20100137208, Jun 3, 2010
Filed:

Sep 17, 2009
Appl. No.:

12/561429
Inventors:

Atul Varadhachary - Houston TX, US
Rick Barsky - Houston TX, US
Karel Petrak - Houston TX, US
Bert O'Malley - Houston TX, US
International Classification:

A61K 38/16
A61P 35/04
US Classification:

514 12
Abstract:

The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies.

Methods And Compositions To Treat Cancer Using Bifunctional Src 3 Shrna
view source
US Patent:

20130259925, Oct 3, 2013
Filed:

Mar 27, 2013
Appl. No.:

13/851464
Inventors:

John J. Nemunaitis - Cedar Hill TX, US
Neil Senzer - Dallas TX, US
Bert W. O'Malley - Houston TX, US
David Lonard - Pearland TX, US
Assignee:

BAYLOR COLLEGE OF MEDICINE - Houston TX
GRADALIS, INC. - Carrollton TX
International Classification:

A61K 31/713
A61K 45/06
C12N 15/113
US Classification:

424450, 514 44 R, 4241301, 4353201, 435375, 600 1
Abstract:

The present invention includes compositions and methods of making and using an expression vector comprising a promoter and a nucleic acid insert operably linked to the promoter, wherein the insert encodes one or more short hairpin RNAs (shRNA) capable of inhibiting an expression of a SRC-3 gene via RNA interference, wherein the one or more shRNA comprise a bifunctional RNA molecule that activates a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of the SRC-3.

Dr. Bert W O'malley, Philadelphia PA - MD (Doctor of Medicine)

view source

Specialties:

Ear, Nose, and Throat

Address:

Philadelphia Office
3400 Spruce St, Philadelphia, PA 19104
8007897366 (Phone), 2156624613 (Fax)

University Penn Hlth Sys OTO
3400 Spruce St, Philadelphia, PA 19104
2156622777 (Phone)

Certifications:

Otolaryngology, 1995

Awards:

Healthgrades Honor Roll

Languages:

English

Hospitals:

Philadelphia Office
3400 Spruce St, Philadelphia, PA 19104

University Penn Hlth Sys OTO
3400 Spruce St, Philadelphia, PA 19104

Hospital of the University of Pennsylvania
3400 Spruce Street, Philadelphia, PA 19104

The Johns Hopkins Hospital
1800 Orleans Street, Baltimore, MD 21287

Education:

Medical School
University of Texas Southwestern Medical Center At Dallas
Graduated: 1988

Dr. Bert W O'malley, Houston TX - MD (Doctor of Medicine)

view source

Specialties:

Endocrinology, Diabetes & Metabolism

Address:

1 Baylor Plz Suite M613, Houston, TX 77030
7137986205 (Phone), 7137985599 (Fax)

LESTER AND SUE SMITH BREAST CENTER
1 Baylor Plz, Houston, TX 77030
7137981600 (Phone), 7137981642 (Fax)

Languages:

English

Education:

Medical School
Univ Of Pittsburgh Sch Of Med
Graduated: 1963

Bert W. O'malley

view source

Specialties:

Otolaryngology, Plastic Surgery within the Head & Neck

Work:

University Pennsylvania Health Systems Otolaryngology & Head & Neck Surgery
3400 Spruce St FL 5, Philadelphia, PA 19104
2156622777 (phone), 2156624613 (fax)

Education:

Medical School
University of Texas Southwestern Medical Center at Dallas
Graduated: 1988

Procedures:

Hearing Evaluation
Inner Ear Tests
Rhinoplasty
Sinus Surgery
Tonsillectomy or Adenoidectomy
Tracheostomy
Skull/Facial Bone Fractures and Dislocations

Conditions:

Acute Pharyngitis
Allergic Rhinitis
Deviated Nasal Septum
Hearing Loss
Laryngeal Cancer

Languages:

English

Description:

Dr. O'Malley graduated from the University of Texas Southwestern Medical Center at Dallas in 1988. He works in Philadelphia, PA and specializes in Otolaryngology and Plastic Surgery within the Head & Neck. Dr. O'Malley is affiliated with Hospital Of The University Of Pennsylvania, Penn Presbyterian Medical Center and Pennsylvania Hospital.