Beth A Badea

US Patent:

6545049, Apr 8, 2003

Filed:

Sep 2, 1999

Appl. No.:

09/388888

Inventors:

Chan K. Hwang - Boulder CO
Marcus F. Boehm - San Diego CA
Beth Ann Badea - San Diego CA
Laura J. Dardashti - Santa Anna CA
Lin Zhang - San Diego CA
Alex M. Nadzan - San Diego CA
Richard A. Heyman - Encinitas CA
Ranjan Mukherjee - San Diego CA
Deepak S. Lala - San Diego CA
Luc J. Farmer - La Jolla CA

Assignee:

Ligand Pharmaceuticals Incorporated - San Diego CA

International Classification:

A61K 3119

US Classification:

514569, 514725, 560500

Abstract:

Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their therapeutic use.

US Patent:

20040019072, Jan 29, 2004

Filed:

Feb 5, 2003

Appl. No.:

10/360580

Inventors:

Chan Hwang - Boulder CO, US
Marcus Boehm - San Diego CA, US
Beth Badea - San Diego CA, US
Laura Dardashti - Santa Anna CA, US
Lin Zhang - San Diego CA, US
Alex Nadzan - San Diego CA, US
Richard Heyman - Encinitas CA, US
Ranjan Mukherjee - San Diego CA, US
Deepak Lala - San Diego CA, US
Luc Farmer - La Jolla CA, US

International Classification:

C07D221/22
C07C251/48
C07C063/44
A61K031/473
A61K031/195
A61K031/198

US Classification:

514/290000, 514/567000, 514/569000, 514/570000, 546/079000, 552/271000, 562/440000, 562/490000

Abstract:

Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their therapeutic use.

US Patent:

57703833, Jun 23, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/475397

Inventors:

Chan Kou Hwang - Boulder CO
Steven K. White - San Diego CA
Youssef L. Bennani - La Jolla CA
Stacie S. Canan Koch - San Diego CA
Beth Ann Badea - San Diego CA
Jonathan J. Hebert - Mission Viejo CA
Luc J. Farmer - La Jolla CA
Alex M. Nadzan - San Diego CA

Assignee:

Ligand Pharmaceuticals, Inc. - San Diego CA

International Classification:

G01N 3353
C07D22106
A61K 3133
C07K 114

US Classification:

435 71

Abstract:

Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.

US Patent:

57703825, Jun 23, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/475514

Inventors:

Chan Kou Hwang - Boulder CO
Steven K. White - San Diego CA
Beth Ann Badea - San Diego CA
Alex M. Nadzan - San Diego CA

Assignee:

Ligand Pharmaceuticals, Inc. - San Diego CA

International Classification:

G01N 3353
C07D22106
A61K 3133
C07K 114

US Classification:

435 71

Abstract:

Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.

US Patent:

57703787, Jun 23, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/472127

Inventors:

Chan Kou Hwang - Boulder CO
Steven K. White - San Diego CA
Youssef L. Bennani - La Jolla CA
Stacie S. Canan Koch - San Diego CA
Beth Ann Badea - San Diego CA
Jonathan J. Hebert - Mission Viejo CA
Alex M. Nadzan - San Diego CA

Assignee:

Ligand Pharmaceuticals, Inc. - San Diego CA

International Classification:

G01N 3353
C07D22106
A61K 3133
C07K 114

US Classification:

435 71

Abstract:

Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.