Bette T M Korber from 5B Angelitos Rd APT B, Santa Fe, NM 87506, age 66

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Location:

5b Angelitos Rd, Santa Fe, NM 87506

Industry:

Biotechnology

Work:

Los Alamos National Laboratory
Scientist
Santa Fe Institute 1991 - 2011
Visiting Faculty
Harvard School of Public Health 1988 - 1990
Post doc

Education:

California Institute of Technology 1981 - 1988
Ph.D., Chemistry

Skills:

Bioinformatics
Molecular Biology
Genomics
Science
Biochemistry
Lifesciences
Virology
Drug Discovery
Genetics

Polyvalent Immunogen
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US Patent:

7172761, Feb 6, 2007
Filed:

May 8, 2003
Appl. No.:

10/431596
Inventors:

Barton F. Haynes - Durham NC, US
Bette T. Korber - Los Alamos NM, US
Robert M. De Lorimier - Durham NC, US
Assignee:

Duke University - Durham NC
The Regents of The University of California - Oakland CA
International Classification:

A61K 39/00
US Classification:

4241921, 4241851, 4241861, 4241881, 4241931, 4242041, 4242081, 530300, 530324, 530350, 530826
Abstract:

The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.

Polyvalent Immunogen
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US Patent:

7195768, Mar 27, 2007
Filed:

Feb 26, 2003
Appl. No.:

10/373592
Inventors:

Barton F. Haynes - Durham NC, US
Bette T. Korber - Los Alamos NM, US
Robert M. De Lorimier - Durham NC, US
Assignee:

Duke University - Durham NC
The Regents of the University of California - Oakland CA
International Classification:

A61K 39/00
US Classification:

4241921, 4241851, 4241881, 4242081, 530326, 530300, 530324, 530325, 530826
Abstract:

The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.

Mosaic Clade M Human Immunodeficiency Virus Type 1 (Hiv-1) Envelope Immunogens
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US Patent:

7951377, May 31, 2011
Filed:

Aug 14, 2008
Appl. No.:

12/192015
Inventors:

Bette T. Korber - Los Alamos NM, US
William Fischer - Los Alamos NM, US
Barton F. Haynes - Durham NC, US
Norman Letvin - Boston MA, US
Beatrice H. Hahn - Birmingham AL, US
Assignee:

Los Alamos National Security, LLC - Los Alamos NM
Duke University - Durham NC
Beth Isreal Deaconess Medical Center - Boston MA
The University of Albama at Birmingham Research Foundation - Birmingham AL
International Classification:

A61K 39/21
US Classification:

4241881, 4242081
Abstract:

The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Nucleic Acids Encoding Modified Human Immunodeficiency Virus Type 1 (Hiv-1) Group M Consensus Envelope Glycoproteins
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US Patent:

8071107, Dec 6, 2011
Filed:

Sep 17, 2004
Appl. No.:

10/572638
Inventors:

Barton F. Haynes - Durham NC, US
Feng Gao - Durham NC, US
Bette T. Korber - Los Alamos NM, US
Beatrice H. Hahn - Birmingham AL, US
George M. Shaw - Birmingham AL, US
Denise Kothe - Birmingham AL, US
Ying Ying Li - Hoover AL, US
Julie Decker - Alabaster AL, US
Assignee:

Duke University - Durham NC
The Regents of the University of California - Oakland CA
The University of Alabama at Birmingham Research Foundation - Birmingham AL
International Classification:

A61K 39/21
C07H 21/04
US Classification:

4242081, 536 2372
Abstract:

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

Immunogenic Compositions Comprising Human Immunodeficiency Virus (Hiv) Mosaic Nef Proteins
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US Patent:

8119140, Feb 21, 2012
Filed:

Aug 23, 2006
Appl. No.:

11/990222
Inventors:

Bette T. Korber - Los Alamos NM, US
Simon Perkins - Los Alamos NM, US
Tanmoy Bhattacharya - Los Alamos NM, US
William M. Fischer - Los Alamos NM, US
James Theiler - Los Alamos NM, US
Norman Letvin - Boston MA, US
Barton F. Haynes - Durham NC, US
Beatrice H. Hahn - Birmingham AL, US
Karina Yusim - Los Alamos NM, US
Carla Kuiken - Los Alamos NM, US
Assignee:

Los Alamos Security, LLC - Los Alamos NM
Beth Israel Deaconess Medical Center - Boston MA
Duke University - Durham NC
The University of Alabama at Birmingham Research Foundation - Birmingham AL
International Classification:

A61K 39/21
US Classification:

4241881, 4242081
Abstract:

The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Polyvalent Immunogen
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US Patent:

20030147888, Aug 7, 2003
Filed:

Nov 7, 2002
Appl. No.:

10/289228
Inventors:

Barton Haynes - Durham NC, US
Bette Korber - Los Alamos NM, US
Robert De Lorimier - Durham NC, US
International Classification:

A61K039/395
A61K039/21
US Classification:

424/144100, 424/208100
Abstract:

The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against IV and to a polyvalent immunogen suitable for use in such a method.

Hiv Envelope V3-Ccr5 Binding Site Immunogen
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US Patent:

20030219452, Nov 27, 2003
Filed:

Nov 27, 2002
Appl. No.:

10/305357
Inventors:

Barton Haynes - Durham NC, US
Bette Korber - Los Alamos NM, US
International Classification:

A61K039/21
C07K014/16
US Classification:

424/188100, 530/350000
Abstract:

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.

Polyvalent Vaccine
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US Patent:

20110150915, Jun 23, 2011
Filed:

Dec 3, 2010
Appl. No.:

12/960287
Inventors:

Bette T. Korber - Los Alamos NM, US
Simon Perkins - Los Alamos NM, US
Tanmoy Bhattacharya - Los Alamos NM, US
William M. Fischer - Los Alamos NM, US
James Theiler - Los Alamos NM, US
Norman Letvin - Boston MA, US
Barton F. Haynes - Durham NC, US
Beatrice H. Hahn - Birmingham AL, US
Karina Yusim - Los Alamos NM, US
Carla Kuiken - Los Alamos NM, US
Assignee:

Los Alamos National Security, LLC - Los Alamos NM
Beth Israel Deaconess Medical Center - Boston MA
Duke University - Durham NC
The University of Alabama at Birmingham Research Foundation - Birmingham AL
International Classification:

A61K 39/21
C07K 14/16
C07H 21/00
C12N 15/63
A61K 39/295
A61P 37/04
A61P 31/18
US Classification:

4241881, 530324, 530350, 536 2372, 4353201, 4242081
Abstract:

The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

Bette T M Korber