Bhairavi R Parikh

US Patent:

7352465, Apr 1, 2008

Filed:

Feb 7, 2005

Appl. No.:

11/053210

Inventors:

Jonathan Fay - San Mateo CA, US
Kevin Nason - Menlo Park CA, US
Bhairavi Parikh - Palo Alto CA, US
John Hammerman - Lincoln CA, US
James Stone - Saratoca CA, US
David Anvar - Sunnyvale CA, US

Assignee:

Aperon Biosystems Corp. - Menlo Park CA

International Classification:

G01N 21/00

US Classification:

356437

Abstract:

The present invention is a system and method of conditioning the sample and surrounding environment of an exhaled breath sensor. It includes (i) using a particular molecular sieve for a triple purpose: (a) maintaining the sensor at a constant relative humidity during storage, (b) equilibrating the incoming breath stream to the same relative humidity as the sensor, and (c) eliminating the analyte from the environment around the sensor during storage. The present invention also includes removal of interfering components from the exhaled breath, such as carbon dioxide, as well as a thermal management technique.

US Patent:

7533558, May 19, 2009

Filed:

Apr 19, 2007

Appl. No.:

11/737631

Inventors:

Bryan Flaherty - Half Moon Bay CA, US
Bhairavi Parikh - Palo Alto CA, US
Kevin Nason - Menlo Park CA, US
David Chazan - Palo Alto CA, US
Jonathan Fay - San Mateo CA, US
John Kaiser - Menlo Park CA, US
James Stone - Saratoga CA, US

Assignee:

Apieron Biosystems Corp. - Palo Alto CA

International Classification:

G01N 33/497

US Classification:

73 233, 422 84

Abstract:

The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

US Patent:

7611671, Nov 3, 2009

Filed:

Oct 14, 2005

Appl. No.:

11/250958

Inventors:

David J. Anvar - Sunnyvale CA, US
David J. Chazan - Palo Alto CA, US
Bryan P. Flaherty - Half Moon Bay CA, US
Bhairavi R. Parikh - Palo Alto CA, US

Assignee:

Aperon Biosystems Corp. - Menlo Park CA

International Classification:

G01N 33/497

US Classification:

422 83, 422 87, 436116, 436118, 436167, 73 232, 73 3102

Abstract:

Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.

US Patent:

8181503, May 22, 2012

Filed:

Apr 9, 2009

Appl. No.:

12/421094

Inventors:

Bryan Flaherty - Half Moon Bay CA, US
Bhairavi Parikh - Palo Alto CA, US
Kevin Nason - Menlo Park CA, US
David Chazan - Palo Alto CA, US
Jonathan Fay - San Mateo CA, US
John Kaiser - Menlo Park CA, US
James Stone - Saratoga CA, US

Assignee:

Aerocrine AB - Solna

International Classification:

G01N 33/497

US Classification:

73 233, 422 84, 600532

Abstract:

The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

US Patent:

8426122, Apr 23, 2013

Filed:

Sep 28, 2011

Appl. No.:

13/247896

Inventors:

Bhairavi Parikh - Palo Alto CA, US
Michael D. Brody - Fremont CA, US
James Stone - Saratoga CA, US
Jonathan D. Halderman - Santa Clara CA, US

Assignee:

Cellscape Corporation - Newark CA

International Classification:

A01N 1/02
A61M 37/00

US Classification:

435 2, 604 601, 604 603, 604 609

Abstract:

A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.

US Patent:

8206311, Jun 26, 2012

Filed:

Apr 1, 2009

Appl. No.:

12/416760

Inventors:

David J. Chazan - Palo Alto CA, US
Bhairavi R. Parikh - Palo Alto CA, US
Bryan P. Flaherty - Half Moon Bay CA, US
David J. Anvar - Sunnyvale CA, US
Brian A. Awabdy - Pleasanton CA, US

Assignee:

Aerocrine AB - Solna

International Classification:

A61B 5/08
G01N 33/497

US Classification:

600532, 73 233, 422 86, 4352871, 435 25

Abstract:

A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NO-free air in a controlled manner, preferably in pulses separated by equilibration periods.

US Patent:

20040017570, Jan 29, 2004

Filed:

Dec 30, 2002

Appl. No.:

10/334625

Inventors:

Bhairavi Parikh - Palo Alto CA, US
Rajiv Parikh - Palo Alto CA, US

International Classification:

G01N021/61

US Classification:

356/437000

Abstract:

The present invention is a device and system for the measurement of substances in exhaled breath. Its basic components include (i) an optional inlet unit to provide controlled air to the subject, (ii) an outlet unit for capturing exhaled breath from the subject, (iii) a sample chamber, (iv) a sensing element, such as a bioactive compound in a sol-gel matrix, (v) a light source, (vi) a detector, (vii) control circuitry, (viii) a signal processor, (ix) a display, and (x) optional storage means.

US Patent:

20050053549, Mar 10, 2005

Filed:

Sep 10, 2003

Appl. No.:

10/659408

Inventors:

Rajiv Parikh - Palo Alto CA, US
Bhairavi Parikh - Palo Alto CA, US
Andrew Newman - Palo Alto CA, US

International Classification:

A61K049/00
A61B005/00

US Classification:

424009100, 600300000

Abstract:

A method for management of asthma and other respiratory conditions is disclosed. This method uses exhaled nitric oxide readings to measure airway inflammation, thereby allowing precise titration of medication. The present invention can also be used to measure patient compliance with prescribed treatment regimes.