Philip Boudjouk - Fargo ND, US Thomas Ready - Page ND, US Bhanu Chauhan - Silver Spring MD, US
International Classification:
C08G077/00
US Classification:
528/010000
Abstract:
A method of preparing a aminofunctional alkoxy polysiloxane is disclosed. The method includes reacting a polyhydrosiloxane with an alcohol reactant containing an aminoalcohol to form the aminofunctional alkoxy polysiloxane. Linear and cyclic aminofunctional alkoxy polysiloxane are also disclosed. A coating composition comprising an aminofunctional alkoxy polysiloxane is also provided.
Antineoplastic Polyalkoxyalkylsiloxanes And Methods Of Use Thereof
Philip Boudjouk - Fargo ND, US Thomas Ready - Page ND, US Shane Stafslien - Fargo ND, US Bhanu Chauhan - Staten Island NY, US
International Classification:
A61K031/695
US Classification:
514/063000
Abstract:
Polyaminofunctional alkoxy polysiloxanes which exhibit antineoplastic activity are disclosed. Pharmaceutical compositions including an effective amount of a polyaminofunctional alkoxy polysiloxane and/or a pharmaceutically acceptable salt thereof are also disclosed. The application also describes methods of suppressing the growth of neoplastic cells and treating neoplastic conditions.
Philip Raymond Boudjouk - Fargo ND Michael Perry Remington - Fargo ND Bhanu Chauhan - Fargo ND
Assignee:
North Dakota State University Research Foundation - Fargo ND
International Classification:
C07F 708 C07F 710
US Classification:
556424
Abstract:
Compounds containing a tetradecachlorocyclohexasilane dianion are prepared by contacting trichlorosilane with a reagent composition comprising a tertiary polyamine. The compound �pedeta. SiH. sub. 2 Cl. sup. +1 !. sub. 2 �Si. sub. 6 Cl. sub. 14. sup. -2 ! wherein pedeta is N,N,N',N",N"-pentaethyldiethylenetriamine is prepared by contacting trichlorosilane with pedeta. The compound �Ph. sub. 4 P. sup. +1 !. sub. 2 �Si. sub. 6 Cl. sub. 14. sup. -2 ! is prepared by contacting trichlorosilane with a mixture of N,N,N',N'-tetraethylethylenediamine and triphenylphosphonium chloride. The tetradecachlorocyclohexasilane dianion can be chemically reduced to cyclohexasilane, a compound useful in the deposition of amorphous silicon films. The tetradecachlorcyclohexasilane dianion can also be contacted with a Grignard reagent to form a dodecaorganocyclohexasilane.