Billy W Martin

US Patent:

6509005, Jan 21, 2003

Filed:

Mar 22, 1999

Appl. No.:

09/273766

Inventors:

Joanne Peart - Richmond VA
Peter R. Byron - Richmond VA
Aron H. Lichtman - Richmond VA
Billy R. Martin - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61L 904

US Classification:

424 45, 514454

Abstract:

The present invention provides therapeutic formulations for solutions of -tetrahydrocannabinol ( THC) to be delivered by metered dose inhalers. The formulations, which utilize non-CFC propellants, provide a stable aerosol-deliverable source of THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy; muscle spasticity; pain; anorexia associated with AIDS wasting syndrome; epilepsy; glaucoma; bronchial asthma; and mood disorders.

US Patent:

6509367, Jan 21, 2003

Filed:

Sep 22, 2001

Appl. No.:

09/682577

Inventors:

Billy R. Martin - Richmond VA
Raj K. Razdan - Gloucester MA
Anu Mahadevan - Woburn MA

Assignee:

Virginia Commonwealth University - Richmond VA
Organix, Inc. - Woburn MA

International Classification:

A61K 31415

US Classification:

514406, 514403, 5483741

Abstract:

Disclosed are pyrazole derivatives of formula I: Where R , R , R , and R are defined as in the specification described. These compounds are antagonists of the brain cannabinoid (CB-1) receptors and could be used as active gradients in pharmaceutical preparations to block or inhibit cannabinoid receptors in mammals.

US Patent:

6563009, May 13, 2003

Filed:

Mar 8, 2002

Appl. No.:

10/009813

Inventors:

George Kunos - Bethesda MD
Billy Martin - Richmond VA
Raj Razdan - Gloucester MA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07C 3917

US Classification:

568743, 514729

Abstract:

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes the cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotuctants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH , and COCH.

US Patent:

6713048, Mar 30, 2004

Filed:

Sep 4, 2001

Appl. No.:

09/944221

Inventors:

Joanne Peart - Richmond VA
Peter R. Byron - Richmond VA
Aron H. Lichtman - Richmond VA
Billy R. Martin - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61L 904

US Classification:

424 45, 514454

Abstract:

The present invention provides therapeutic formulations for solutions of -tetrahydrocannabinol ( THC) to be delivered by metered dose inhalers. The formulations, which use, non-CFC propellants, provide a stable aerosol-deliverable source of THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.

US Patent:

6800770, Oct 5, 2004

Filed:

Jan 17, 2003

Appl. No.:

10/346164

Inventors:

Billy Martin - Richmond VA
Raj K. Razdan - Gloucester MA
Anu Mahadevan - Woburn MA
David Baker - London, GB

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07C23305

US Classification:

554 51, 554 54, 554 61, 558414, 514509, 514521, 514627

Abstract:

The invention compounds and methods for the treatment of motor disorders. In particular, the invention provides eicosanoid analogs which are effective in ameliorating motor disorders such as spasticity caused by multiple sclerosis (MS).

US Patent:

7179800, Feb 20, 2007

Filed:

Apr 15, 2003

Appl. No.:

10/413539

Inventors:

Billy R. Martin - Richmond VA, US
Raj K. Razdan - Gloucester MA, US

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31/33
C07C 39/12

US Classification:

514183, 568731

Abstract:

Compounds of the formula:.

US Patent:

7279500, Oct 9, 2007

Filed:

Jun 24, 2003

Appl. No.:

10/601757

Inventors:

Billy R. Martin - Richmond VA, US
Raj K. Razdan - Gloucester MA, US
Roger G. Pertwee - Cults, GB

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31/35

US Classification:

514454, 549390

Abstract:

Cannabinoid agonists and antagonists are provided for use in the treatment of disorders such as acute and chronic pain, inflammation, loss of appetite, convulsions, multiple sclerosis, nausea and vomiting. The cannabinoid agonists and antagonists contain a sulfonamide moiety incorporated into the cannabinoid side chain, and the side chain itself may be saturated or unsaturated.

US Patent:

7285687, Oct 23, 2007

Filed:

Jun 20, 2002

Appl. No.:

10/512468

Inventors:

Billy R. Martin - Richmond VA, US
Raj K. Razdan - Gloucester MA, US

Assignee:

Virginia Commonwealth University - Richmond VA
Organix Inc. - Woburn MA

International Classification:

C07C 27/10

US Classification:

568700

Abstract:

Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabinoid receptors, commonly designated the CB2 receptor class. The compounds are useful for therapy, especially in the treatment of pain, inflammation and autoimmune disease.