Binh Quoc Vu

US Patent:

20230049952, Feb 16, 2023

Filed:

Jun 15, 2021

Appl. No.:

17/348488

Inventors:

- Cranbury NJ, US
David Mack - Menlo Park CA, US
Binh Vu - North Caldwell NJ, US
Thomas Davis - South Orange NJ, US
Melissa Dumble - Watchung NJ, US

International Classification:

A61K 31/454
A61K 31/4045
A61P 35/00

Abstract:

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Address:

196 Park Sharon Dr, San Jose, CA 95136

VIN:

5FNYF28258B024181

Make:

HONDA

Model:

PILOT

Year:

2008