Bo A Qiu

US Patent:

6913936, Jul 5, 2005

Filed:

Oct 17, 2001

Appl. No.:

09/982265

Inventors:

Bo Qiu - East Brunswick NJ, US
Guobao Zhang - Piscataway NJ, US
Stanley Stein - East Brunswick NJ, US
Leonard H Sigal - Plainfield NJ, US
Michael Brunner - Columbus NJ, US
Michael Katz - Freehold NJ, US

Assignee:

University of Medicine and Dentistry of New Jersey - New Brunswick NJ

International Classification:

G01N033/545
G01N033/546
C07K017/06
C07K017/08

US Classification:

436531, 435 795, 435188, 435 5, 436525, 436526, 436533, 436544, 436545, 436546, 436811, 436823, 5303911, 5303919, 530402, 530404, 530405, 530406, 530413

Abstract:

A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of kits for immunological assays.

US Patent:

7045134, May 16, 2006

Filed:

Oct 17, 2001

Appl. No.:

09/982259

Inventors:

Bo Qiu - East Brunswick NJ, US
Guobao Zhang - Piscataway NJ, US
Stanley Stein - East Brunswick NJ, US
Leonard Sigal - Plainfield NJ, US
Michael Brunner - Columbus NJ, US
Michael Katz - Freehold NJ, US

Assignee:

University of Medicine and Dentistry of New Jersey - New Brunswick NJ

International Classification:

A61K 39/02
A61K 49/00
A61K 39/08
A61K 39/00

US Classification:

4241901, 424 91, 424 92, 4241841, 4241851, 4242341, 435 41, 435243, 530300, 530350

Abstract:

Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.

US Patent:

7740882, Jun 22, 2010

Filed:

Jun 29, 2005

Appl. No.:

11/170652

Inventors:

Srinivasan Ramanathan - Mountain View CA, US
Stanley Stein - East Brunswick NJ, US
Michael Leibowitz - Manalapan NJ, US
Patrick J. Sinko - Lebanon NJ, US
Tamara Minko - Edison NJ, US
Gregory C. Williams - Warren NJ, US
Xiaoping Zhang - Piscataway NJ, US
Shahrair Pooyan - Monnt Kisco NY, US
Seong Hee Park - Piscataway NJ, US
Bo Qiu - East Brunswick NJ, US
Pankaj Paranjpe - Piscataway NJ, US

International Classification:

A61K 9/20
A61K 38/04
A61K 38/00
A61K 51/00

US Classification:

424465, 530327, 514 2, 424 169

Abstract:

The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

US Patent:

20020076443, Jun 20, 2002

Filed:

Jun 18, 2001

Appl. No.:

09/883842

Inventors:

Stanley Stein - East Brunswick NJ, US
Bo Qiu - East Brunswick NJ, US

International Classification:

A61K009/14

US Classification:

424/486000, 424/488000

Abstract:

The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.

US Patent:

20020106706, Aug 8, 2002

Filed:

Oct 17, 2001

Appl. No.:

09/982264

Inventors:

Bo Qiu - Piscataway NJ, US
Stanley Stein - East Brunswick NJ, US
Guobao Zhang - Piscataway NJ, US
Leonard Sigal - Plainfield NJ, US
Michael Brunner - Columbus NJ, US
Michael Katz - Freehold NJ, US

International Classification:

G01N033/554
G01N033/569
C07K014/195

US Classification:

435/007320, 530/350000

Abstract:

Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.

US Patent:

20020122785, Sep 5, 2002

Filed:

May 1, 2002

Appl. No.:

10/137049

Inventors:

Stanley Stein - East Brunswick NJ, US
Guobao Zhang - Piscataway NJ, US
Bo Qiu - New Brunswick NJ, US

International Classification:

A61K031/74

US Classification:

424/078270

Abstract:

This invention pertains to disulfide-linked conjugates of therapeutic agents containing at least one thioamide group with polymer comprising at least one thiol group, so as to provide a controlled release pharmaceutical composition for administration to animals for the prophylaxis or treatment of various conditions or diseases. The therapeutic agent conjugate may comprise an inactive or weakly active prodrug form which may be converted into the original therapeutic compound by the natural action of reducing agents in vivo. The composition may comprise a mixture of polymers each with a different thioamide-containing agent attached, or a polymer conjugated with a mixture of thioamide-containing agents. Modified properties of the therapeutic compound potentially provided by the polymer itself, as well as by other compounds also appended to the polymer, include but are not limited to greater water solubility, longer in-vivo half-life (due to larger size of the conjugate), slower release from a sustained-release depot (due to larger size of the conjugate), better oral bioavailability and tissue-specific targeting.

US Patent:

20030031674, Feb 13, 2003

Filed:

Oct 17, 2001

Appl. No.:

09/982300

Inventors:

Bo Qiu - East Brunswick NJ, US
Guobao Zhang - Piscataway NJ, US
Stanley Stein - East Brunswick NJ, US
Leonard Sigal - Plainfield NJ, US
Michael Brunner - Columbus NJ, US
Michael Katz - Freehold NJ, US

International Classification:

G01N033/53
A61K039/395
A61K039/00

US Classification:

424/178100, 424/184100, 435/007100

Abstract:

Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.

US Patent:

20030040127, Feb 27, 2003

Filed:

Oct 17, 2001

Appl. No.:

09/982287

Inventors:

Bo Qiu - Piscataway NJ, US
Stanley Stein - East Brunswick NJ, US
Guobao Zhang - Piscataway NJ, US
Leonard Sigal - Plainfield NJ, US
Michael Brunner - Columbus NJ, US
Michael Katz - Freehold NJ, US

International Classification:

G01N033/543

US Classification:

436/518000

Abstract:

Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay