Bradley J Swanson

US Patent:

20100167952, Jul 1, 2010

Filed:

Sep 3, 2009

Appl. No.:

12/553251

Inventors:

Thomas Albert - Madison WI, US
Jeff Jeddeloh - Verona WI, US
Bradley Swanson - Madison WI, US

International Classification:

C07H 21/04
C40B 40/06

US Classification:

506 16, 536 242

Abstract:

The present invention provides for compositions, methods and systems for targeted sequence enrichment. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in microarray assays by suppressing secondary capture of non-target nucleic acid sequences.

US Patent:

20210017494, Jan 21, 2021

Filed:

Oct 5, 2020

Appl. No.:

17/063204

Inventors:

- Madison WI, US
Xin ZHANG - Madison WI, US
Andrew J. BRANDL - Madison WI, US
Deepika RAJESH - Madison WI, US
Bradley SWANSON - Madison WI, US
Christie MUNN - Madison WI, US
Sarah A. BURTON - Madison WI, US
Wen Bo WANG - Madison WI, US

Assignee:

FUJIFILM Cellular Dynamics, Inc. - Madison WI

International Classification:

C12N 5/0783
C12N 5/0784
C12N 5/0789
C12N 15/85
C12N 5/0781
C12N 15/86

Abstract:

Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.

US Patent:

20200263139, Aug 20, 2020

Filed:

Oct 5, 2017

Appl. No.:

16/339676

Inventors:

- Madison WI, US
Xin ZHANG - Madison WI, US
Andrew J. BRANDL - Madison WI, US
Deepika RAJESH - Madison WI, US
Bradley SWANSON - Madison WI, US
Christie MUNN - Madison WI, US
Sarah BURTON - Madison WI, US
Wen Bo WANG - Madison WI, US

Assignee:

FUJIFILM Cellular Dynamics, Inc. - Madison WI

International Classification:

C12N 5/074
C12N 5/0783
C12N 5/0784
C12N 5/0789

Abstract:

Provided herein are methods for the efficient in vitro differentiation of HLA homozygous blood cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into HLA homozygous immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.

US Patent:

20200123501, Apr 23, 2020

Filed:

Apr 18, 2018

Appl. No.:

16/606120

Inventors:

- Madison WI, US
Xin ZHANG - Madison WI, US
Andrew J. BRANDL - Madison WI, US
Deepika RAJESH - Madison WI, US
Bradley SWANSON - Madison WI, US
Christie MUNN - Madison WI, US
Sarah BURTON - Madison WI, US
Wen Bo WANG - Madison WI, US
Ethan McLEOD - Madison WI, US

Assignee:

FUJIFILM Cellular Dynamics, Inc. - Madison WI

International Classification:

C12N 5/0783
A61K 35/17
A61K 35/545
C07K 14/725

Abstract:

Provided herein are methods for the production of antigen-specific effector T cells and NK cells from pluripotent stem cells which express a chimeric antigen receptor (CAR). Further provided herein are methods for the adoptive cell therapy by administering the effector T cells and/or NK cells provided herein.

US Patent:

20180305664, Oct 25, 2018

Filed:

Oct 20, 2016

Appl. No.:

15/769386

Inventors:

- Madison WI, US
Xin ZHANG - Madison WI, US
Andrew J. BRANDL - Madison WI, US
Deepika RAJESH - Madison WI, US
Bradley SWANSON - Madison WI, US
Christie MUNN - Madison WI, US
Sarah A. BURTON - Madison WI, US
Wen Bo WANG - Madison WI, US

Assignee:

FUJIFILM Cellular Dynamics, Inc. - Madison WI

International Classification:

C12N 5/0783
C12N 5/0781
C12N 5/0784
C12N 15/86

Abstract:

Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.

US Patent:

20180179496, Jun 28, 2018

Filed:

Oct 5, 2017

Appl. No.:

15/725931

Inventors:

- Madison WI, US
Anne STROUSE - Madison WI, US
Sarah BURTON - Madison WI, US
Christie MUNN - Madison WI, US
Bradley SWANSON - Madison WI, US

International Classification:

C12N 5/078
C12N 5/0783
C12N 5/071
C12N 5/079

Abstract:

Provided herein are methods for the efficient in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells with disruption of the MeCP2 gene into various erythroid, myeloid, lymphoid, or endoderm lineages, particularly mature erythrocytes. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the precursor cells.