Brian Craig Bates

US Patent:

20030022211, Jan 30, 2003

Filed:

Jun 7, 2002

Appl. No.:

10/166221

Inventors:

Maria Blatcher - Moorestown NJ, US
Brian Bates - Chelmsford MA, US
Janet Paulsen - Londonderry NH, US

Assignee:

Wyeth - Madison NJ

International Classification:

C12Q001/68
C07H021/04
C12P021/02
C12N005/06
C07K014/705

US Classification:

435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200

Abstract:

The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.

US Patent:

20030149998, Aug 7, 2003

Filed:

Nov 13, 2002

Appl. No.:

10/293983

Inventors:

Maria Blatcher - Moorestown NJ, US
Janet Paulsen - Londonderry NH, US
Brian Bates - Chelmsford MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

C12Q001/68
A01K067/00
C07H021/04
C12N009/64
C12P021/02
C12N005/06

US Classification:

800/008000, 435/006000, 435/069100, 435/325000, 435/320100, 435/226000, 536/023200

Abstract:

The present invention relates generally to the fields of neuroscience, bioinformatics and molecular biology. More particularly, the invention relates to newly identified polynucleotides that encode G-protein coupled receptors (GPCRs), the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. The invention relates also to identifying compounds which may be agonists, antagonists and/or inhibitors of GPCRs, and therefore potentially useful in therapy.

US Patent:

20070031860, Feb 8, 2007

Filed:

Apr 3, 2006

Appl. No.:

11/396960

Inventors:

Maria Blatcher - Moorestown NJ, US
Brian Bates - Chelmsford MA, US
Janet Paulsen - Londonderry NH, US

Assignee:

Wyeth - Madison NJ

International Classification:

C12Q 1/68
G01N 33/567
C07H 21/04
C12P 21/06
C07K 14/705
C07K 16/28

US Classification:

435006000, 435007200, 435069100, 435320100, 435325000, 530350000, 530388220, 536023500

Abstract:

The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.

US Patent:

20090255004, Oct 8, 2009

Filed:

Mar 4, 2009

Appl. No.:

12/397761

Inventors:

Maria Blatcher - Moorestown NJ, US
Brian Gaither Bates - Chelmsford MA, US
Janet Elizabeth Paulsen - Londonderry NH, US

Assignee:

WYETH - Madison NJ

International Classification:

A01K 67/027
C12N 15/12
C12N 15/85
C07K 14/47
C07K 16/18
G01N 33/566
C12Q 1/68
C12N 5/00

US Classification:

800 14, 536 235, 4353201, 530350, 5303879, 436501, 435 6, 435375

Abstract:

The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.