Brian J Devlin

US Patent:

7795359, Sep 14, 2010

Filed:

Mar 1, 2006

Appl. No.:

11/365546

Inventors:

Brian Gerrard Devlin - Suwanee GA, US
Troy V. Holland - Suwanee GA, US
Dawn Alison Smith - Duluth GA, US
Alexander Azzawi - Mainz, DE

Assignee:

Novartis AG - Basel

International Classification:

C08F 2/00
C08G 85/00

US Classification:

526 64, 526 74, 526 78, 525 53

Abstract:

The invention provides a continuous-flow process for producing a polymeric material. The process of the invention comprises the steps of: introducing at least two solutions, each comprising one or more reactants, into a microreactor to mix the two solutions to form a reacting solution, wherein the one or more reactants are selected from the group consisting of a monomer, an initiator, a coupling agent, a prepolymer, a macromer, and mixtures thereof; feeding continuously the reacting solution into a flow-through polymerization reactor in a coil form, wherein the flow-through polymerization reactor is capable of providing a residence time sufficient for (co)polymerizing the reactants to form a polymer with a desired polydispersity, wherein the flow-through polymerization reactor is immersed in an ultrasonic bath to minimize or substantially eliminate unwanted high-molecular-weight fractions of the polymer.

US Patent:

7977430, Jul 12, 2011

Filed:

Nov 17, 2004

Appl. No.:

10/991124

Inventors:

Brian Gerrard Devlin - Suwanee GA, US
Mireille Tena - Daettwilerstrasse, CH

Assignee:

Novartis AG - Basel

International Classification:

C08F 8/00
C08G 18/67
G02C 7/02

US Classification:

525131, 525123, 525127, 525128, 525455, 525459, 522 90, 522 97, 522173, 522174, 351160 H, 351160 R

Abstract:

The present invention provides a water-soluble crosslinkable polyurea prepolymer. The crosslinkable polyurea prepolymer of the invention is prepared by reacting an amine- or isocyanate-capped polyurea with a multifunctional compound having at least one one ethylenically unsaturated group and a function group coreactive with the capping amine or isocyanate groups of the amine- or isocyanate-capped polyurea. The amine- or isocyanate-capped polyurea is a copolymerization production of: (a) at least one poly(oxyalkylene)diamine, (b) optionally at least one organic di- or poly-amine, (c) optionally at least one diisocyanate, and (d) at least one polyisocyanate. The crosslinkable polyurea prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a medical device, preferably an ophthalmic device, more preferably a contact lens.

US Patent:

8318059, Nov 27, 2012

Filed:

Jun 16, 2009

Appl. No.:

12/456409

Inventors:

Brian Gerrard Devlin - Suwanee GA, US
Arturo Norberto Medina - Duluth GA, US
Karen Belinda Sentell - Alpharetta GA, US
Stephen Raymond Perreault - Norcross GA, US
Mireille Tena - Alpharetta GA, US

Assignee:

Novartis AG - Basel

International Classification:

B29C 71/00

US Classification:

264 26, 264232, 264340, 422 27, 422 28

Abstract:

The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

US Patent:

20040116564, Jun 17, 2004

Filed:

Nov 25, 2003

Appl. No.:

10/723680

Inventors:

Brian Devlin - Suwanee GA, US
Arturo Medina - Duluth GA, US
Karen Sentell - Alpharetta GA, US
Stephen Perreault - Norcross GA, US
Mireille Tena - Alpharetta GA, US

International Classification:

B29D011/00
C08K005/09

US Classification:

524/241000, 264/001320, 264/001360, 264/002600, 524/284000

Abstract:

The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

US Patent:

20050056954, Mar 17, 2005

Filed:

Sep 8, 2004

Appl. No.:

10/936031

Inventors:

Brian Devlin - Suwanee GA, US
Mireille Tena - Baden-Daettwil, CH
Norberto Medina - Duluth GA, US

International Classification:

B29D011/00

US Classification:

264001320, 264001360

Abstract:

The instant invention pertains to a method and a fluid composition for producing contact lenses with relatively high edge quality and with relatively high precision and fidelity in reproducing a desired lens design. The method of the invention involves: a mold which has a first mold half with a first molding surface and a second mold half with a second molding surface, wherein the first and second mold halves are configured to receive each other such that the cavity is formed between the first and second molding surfaces which define the opposite two surfaces of a contact lens to be produced; a spatial limitation of actinic radiation to define the edge of the contact lens to be produced; and addition of a radical scavenger in a fluid composition comprising a lens-forming material to reduce substantially the crosslinking/polymerizing, caused by diffused, scattered and/or reflected incident actinic radiation, of the fluid composition outside of and around the spatial limitation of actinic radiation.

US Patent:

20110230588, Sep 22, 2011

Filed:

May 24, 2011

Appl. No.:

13/114338

Inventors:

Brian Gerrard Devlin - Suwanee GA, US
Mireille Tena - Baden-Daettwil, CH
Norberto Arturo Medina - Duluth GA, US

International Classification:

G02C 7/04
C08L 29/04
C08L 75/16
C08L 75/02

US Classification:

523106

Abstract:

The instant invention pertains to a method and a fluid composition for producing contact lenses with relatively high edge quality and with relatively high precision and fidelity in reproducing a desired lens design. The method of the invention involves: a mold which has a first mold half with a first molding surface and a second mold half with a second molding surface, wherein the first and second mold halves are configured to receive each other such that the cavity is formed between the first and second molding surfaces which define the opposite two surfaces of a contact lens to be produced; a spatial limitation of actinic radiation to define the edge of the contact lens to be produced; and addition of a radical scavenger in a fluid composition comprising a lens-forming material to reduce substantially the crosslinking/polymerizing, caused by diffused, scattered and/or reflected incident actinic radiation, of the fluid composition outside of and around the spatial limitation of actinic radiation.